IUPAC_name = N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide

PubChem= 10425450
C = 19 | H = 23 | N = 3 | O = 1
molecular_weight = 309.405 g/mol
smiles = c3ccc(cc3C)NC(=O)CN2CCC(CC2)c1ccccn1
protein_bound =
metabolism =
excretion =
licence_EU =
pregnancy_category =
legal_UK =

A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D4 subtype, with significantly improved selectivity over older D4-preferring compounds such as PD-168,077 and CP-226,269. [Moreland RB, Patel M, Hsieh GC, Wetter JM, Marsh K, Brioni JD. A-412997 is a selective dopamine D4 receptor agonist in rats. "Pharmacology, Biochemistry and Behaviour". 2005 Sep;82(1):140-7. PMID 16153699] It is unclear what applications this drug might be used for, but in animal tests it induced penile erection and improved cognitive performance in rats. [Browman KE, Curzon P, Pan JB, Molesky AL, Komater VA, Decker MW, Brioni JD, Moreland RB, Fox GB. A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. "Pharmacology, Biochemistry and Behaviour". 2005 Sep;82(1):148-55. PMID 16154186] Also unlike other dopamine agonists, selective D4 agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs. [Osinski MA, Uchic ME, Seifert T, Shaughnessy TK, Miller LN, Nakane M, Cox BF, Brioni JD, Moreland RB. Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. "Pharmacology, Biochemistry and Behaviour". 2005 May;81(1):211-9. PMID 15894081]


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • 贬义 — (貶義, 贬义) 字句裡含有的不贊成或壞的意思。 枕書 《博物記趣‧乙丑說牛》: “其實, ‘青牛’並不一定有貶義。” …   Big Chineese Encyclopedy

  • Eugène Louis Lami — Ankunft der Königin Viktoria in Schloss Eu Eugène Louis Lami (* 12. Januar 1800 in Paris; † 19. Dezember 1890 ebenda) war ein französischer Maler. Lami war Schüler in den Ateliers von Antoine Jean Gros und Horace Vernet und konnte mit deren… …   Deutsch Wikipedia

  • Compagnie du Canada — Cette page d’homonymie répertorie les différents sujets et articles partageant un même nom. Compagnie du Canada est : le nom français donné à la Canada Company. le nom donné parfois à la Compagnie de la Nouvelle France. Catégorie : Homonymie …   Wikipédia en Français

  • πέμποις — πέμπω send pres opt act 2nd sg …   Greek morphological index (Ελληνική μορφολογικούς δείκτες)

  • undermountain — n …   Useful english dictionary

  • Берёзов Яр (Лебединский район) — У этого термина существуют и другие значения, см. Берёзов Яр. Село Берёзов Яр укр. Березів Яр Страна Украин …   Википедия

  • Dopamine — For other uses, see Dopamine (disambiguation). Dopamine …   Wikipedia

  • Dopamine receptor D4 — Identifiers Symbols DRD4; D4DR External IDs OMIM:  …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.