CAS number 2942-42-9
PubChem 1893
ChemSpider 1821 YesY
Jmol-3D images Image 1
Molecular formula C7H5N3O2
Molar mass 163.1335
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

7-Nitroindazole, or 7-NI, is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. Nitroindazole acts as a selective inhibitor for neuronal nitric oxide synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO).[1] Nitric oxide can diffuse through the plasma membrane into neighbouring cells, allowing cell signalling, so nitroindazole indirectly inhibits this signalling process.[2][3][4] Other inhibitors exist such as 3-bromo-7-nitroindazole, which is more potent but less specific,[5] or NPA (N-propyl-L-arginine), which acts on a different site.[6]



7-Nitroindazole is under investigation as a possible protective agent against nerve damage caused by excitotoxicity or neurodegenerative diseases.[1][7] It may act by reducing oxidative stress or by decreasing the amount of peroxynitrite formed in these tissues.

See also


  1. ^ a b Southan GJ, Szabó C (February 1996). "Selective pharmacological inhibition of distinct nitric oxide synthase isoforms". Biochem. Pharmacol. 51 (4): 383–94. doi:10.1016/0006-2952(95)02099-3. PMID 8619882. 
  2. ^ Moore PK, Wallace P, Gaffen Z, Hart SL, Babbedge RC (September 1993). "Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects". Br. J. Pharmacol. 110 (1): 219–24. PMC 2175981. PMID 7693278. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175981. 
  3. ^ Babbedge RC, Bland-Ward PA, Hart SL, Moore PK (September 1993). "Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles". Br. J. Pharmacol. 110 (1): 225–8. PMC 2175991. PMID 7693279. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175991. 
  4. ^ Moore PK, Babbedge RC, Wallace P, Gaffen ZA, Hart SL (February 1993). "7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure". Br. J. Pharmacol. 108 (2): 296–7. PMC 1907983. PMID 7680591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1907983. 
  5. ^ Gammie SC, Olaghere-da Silva UB, Nelson RJ (July 2000). "3-bromo-7-nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs maternal aggression and citrulline immunoreactivity in prairie voles". Brain Res. 870 (1-2): 80–6. doi:10.1016/S0006-8993(00)02404-5. PMID 10869504. http://linkinghub.elsevier.com/retrieve/pii/S0006-8993(00)02404-5. 
  6. ^ Kampf C, Roomans GM (May 2001). "Effects of hypochlorite on cultured respiratory epithelial cells". Free Radic. Res. 34 (5): 499–511. doi:10.1080/10715760100300441. PMID 11378533. 
  7. ^ Schulz JB, Matthews RT, Klockgether T, Dichgans J, Beal MF (September 1997). "The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases". Mol. Cell. Biochem. 174 (1-2): 193–7. doi:10.1023/A:1006852306789. PMID 9309687. 

External links

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Endothelial NOS — Nitric oxide synthase 3 (endothelial cell) Rendering of 1M9J …   Wikipedia

  • Nitric oxide synthase — Identifiers EC number CAS number 125978 95 2 …   Wikipedia

  • Indazole — Chembox new ImageFile = Indazol.svg ImageSize = 120px IUPACName = 1 H indazole OtherNames = Section1 = Chembox Identifiers CASNo = 271 44 3 PubChem = 9221 SMILES = C1=CC=C2C(=C1)C=NN2 Section2 = Chembox Properties Formula = C7H6N2 MolarMass = 118 …   Wikipedia

  • NMDA receptor antagonist — Ketamine, one of the most common NMDA receptor antagonists. NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N methyl d aspartate receptor (NMDAR). They are used as anesthesia for animals …   Wikipedia

  • NOS1 — Nitric oxide synthase 1 (neuronal) Rendering of 1b8q …   Wikipedia

  • NMDA-антагонист — Кетамин, распространённый NMDA антагонист Антагонисты NMDA рецептора, или NMDA антагонисты (иногда «НМДА антагонисты»)  класс анестетиков, ингибирующих д …   Википедия

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.