Furazolidone

Furazolidone
Systematic (IUPAC) name
3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat.  ?
Legal status  ?
Routes Oral-Local
Identifiers
CAS number 67-45-8 YesY
ATC code G01AX06
PubChem CID 3435
DrugBank DB00614
ChemSpider 3317 YesY
UNII 5J9CPU3RE0 YesY
KEGG C07999 N
ChEMBL CHEMBL1103 N
Chemical data
Formula C8H7N3O5 
Mol. mass 225.16
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Furazolidone is a nitrofuran antibacterial. It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M.

Contents

Uses

It is used to treat diarrhoea and enteritis caused by bacteria or protozoan infections.

It has also been used in aquaculture.[1]

Protozoan

Furazolidone is also used for giardiasis (due to Giardia lamblia), though it is not a first line treatment.[2]

Bacterial

Furazolidone is also used to treat traveler's diarrhoea, cholera, and bacteremic salmonellosis.

As a veterinary medicine, furazolidone has been used with some success to treat salmonids for Myxobolus cerebralis infections.

Use in treating Helicobacter pylori infections has been proposed.[3]

Mechanism

It is believed to work by crosslinking of DNA.[4]

Side effects

Furazolidone is no longer available in the US. Though an effective antibiotic when all others fail, against extremely drug resistant infections, it has many side effects, and as with other nitrofurans generally, minimum inhibitory concentrations also produce systemic toxicity (tremors, convulsions, peripheral neuritis, gastrointestinal disturbances, depression of spermatogenesis.) Nitrofurans are recognized by FDA as mutagens/carcinogens, and can no longer be used since 1991.[5]

References

  1. ^ Meng J, Mangat SS, Grudzinski IP, Law FC (1998). "Evidence of 14C-furazolidone metabolite binding to the hepatic DNA of trout". Drug Metabol Drug Interact 14 (4): 209–19. PMID 10694929. 
  2. ^ Petri WA (February 2005). "Treatment of Giardiasis" ([dead link]). Curr Treat Options Gastroenterol 8 (1): 13–17. doi:10.1007/s11938-005-0047-3. PMID 15625030. http://www.treatment-options.com/1092-8472/8/13. 
  3. ^ Machado RS, Silva MR, Viriato A (2008). "Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children". Jornal de pediatria 84 (2): 160–5. doi:10.2223/JPED.1772. PMID 18372934. 
  4. ^ "DrugBank: Showing Furazolidone (DB00614)". http://www.drugbank.ca/drugs/DB00614. Retrieved 2008-12-19. 
  5. ^ http://caraga.da.gov.ph/services/banmed-Nitrofurans.htm

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Look at other dictionaries:

  • furazolidone — Has antibacterial and antiprotozoal activity against enteric organisms; used in the treatment of bacterial enteritis and diarrhea. * * * fu·ra·zol·i·done .fyu̇r ə zäl ə .dōn n an antimicrobial drug C8H7N3O5 used against bacteria and some… …   Medical dictionary

  • furazolidone — noun Etymology: furfural + azole + ide + one Date: 1955 an antimicrobial drug C8H7N3O5 used against bacteria and some protozoa especially in infections of the gastrointestinal tract …   New Collegiate Dictionary

  • furazolidone — /fyoor euh zol i dohn /, n. Pharm. a nitrofuran, C8H7N3O5, that is used in the treatment of giardiasis, and bacterial gastroenteritis and dysentery. [1950 55; prob. fur(anyl) + (ox)azolid(in)one, two of its chemical components] * * * …   Universalium

  • furazolidone — noun An antibacterial agent used to treat diarrhoea and enteritis caused by bacteria or protozoan infections …   Wiktionary

  • furazolidone — fu·ra·zol·i·done …   English syllables

  • furazolidone — ˌfyu̇rəˈzälə̇ˌdōn, zȯl noun ( s) Etymology: fur + azole + ide + one : an antimicrobial drug C8H7N3O5 used against bacteria and some protozoa especially in infections of the gastrointestinal tract * * * /fyoor euh zol i dohn /, n. Pharm. a… …   Useful english dictionary

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