Phendimetrazine

Phendimetrazine
Systematic (IUPAC) name
3,4-dimethyl-2-phenylmorpholine
Clinical data
Trade names Bontril
AHFS/Drugs.com monograph
Pregnancy cat. C (US)
Legal status C-III (US)
Routes Oral
Pharmacokinetic data
Bioavailability Peak plasma levels occur within 1 to 3 hours. Absorption is usually complete by 4 to 6 hours
Metabolism Hepatic
Half-life 19-24 hours
Excretion Urinary elimination
Identifiers
CAS number 634-03-7
ATC code None
PubChem CID 12460
DrugBank DB01579
ChemSpider 11950 YesY
UNII AB2794W8KV YesY
KEGG D08347 YesY
ChEMBL CHEMBL1744 YesY
Chemical data
Formula C12H17NO 
Mol. mass 191.27 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Phendimetrazine (Bontril, Adipost, Anorex-SR, Appecon, Melfiat, Obezine, Phendiet, Plegine, Prelu-2, Statobex) is a stimulant drug of the morpholine chemical class used as an appetite suppressant.[1]

Contents

Pharmacology

Phendimetrazine functions as a prodrug to phenmetrazine, and approximately 30% of any given oral dose is converted into it. Phendimetrazine can essentially be thought of as an extended release and less abusable version of phenmetrazine. Phenmetrazine (and therefore phendimetrazine as well) acts as a norepinephrine-dopamine releasing agent (NDRA).[2]

Its structure incorporates the backbone of methamphetamine, a potent CNS stimulant. Whilst adding an N-methyl group to the structure of amphetamine significantly increases its potency and bioavailability, in the case of phendimetrazine the added methyl group results in the compound becoming virtually inactive, at least until the methyl group is removed by the body's metabolism. This results in a steady, continued activation of the drug in the body, both lowering abuse potential and allowing for once-daily administration. However, the abuse potential is significantly high that it is only rarely prescribed today.

Legality

Phendimetrazine.jpg

Phendimetrazine is as potent as amphetamine and is a Schedule III drug under the Convention on Psychotropic Substances. In the United States, phendimetrazine is a Schedule III controlled substance under the Uniform Controlled Substances Act of 1970.

According to the "List of psychotropic substances under international control", phendimetrazine is a Schedule IV controlled substance.[3] Phendimetrazine is listed as a Schedule III substance under the U.S. Controlled Substance Act in the 2007 Drug Identification Bible, pg 615 and under Section 11056(b)(6) California Health and Safety Code.

See also

References


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Look at other dictionaries:

  • phendimetrazine — noun A particular drug used for weight loss, metabolized by the body into phenmetrazine …   Wiktionary

  • phendimetrazine — phen·di·met·ra·zine .fen dī me trə .zēn n an appetite suppressant that is a sympathetic amine with pharmacological activity similar to the amphetamines and is administered orally usu. in the form of its bitartrate C12H17NO·C4H6O6 to assist weight …   Medical dictionary

  • phendimetrazine tartrate — An anorexic agent. * * * phen·di·met·ra·zine tar·trate (fen″di metґrə zēn) [USP] a sympathomimetic amine, related to amphetamine, used as an oral anorectic in the control of exogenous obesity …   Medical dictionary

  • Phenmetrazine — Systematic (IUPAC) name 3 methyl 2 phenylmorpholine Clinical data Pregnancy cat.  ? …   Wikipedia

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