Chugai Pharmaceutical Co.


Chugai Pharmaceutical Co.
Chugai Pharmaceutical Co., Ltd.
Type Incorporation
Headquarters

Nihonbashi Mitsui Tower, Nihonbashi Muromachi 2-1-1, Chūō, Tokyo

On the registration Headquarter: Tokyo Kita (Tokyo)
Website [1]

Chugai Pharmaceutical Co., Ltd. is a subsidiary drug manufacturer operating in Japan controlled by Hoffmann–La Roche who owns a 52% majority of the company. Previous to Roche's takeover in 2002, Chugai was a pioneering discoverer of many important pharmaceutical compounds.

Contents

History

  • 1961 developed patents for synthesis vitamin A)
  • 1995 acute promyelocytic sphere of drug treatment leukemia "BESANOIDO" was released.
  • 1996 anti-viral chemotherapeutic agent "HAIBIDDO" released (HIV reverse transcriptase inhibitor)
  • 1997 HIV protease inhibitor "INBIRAZE" released
  • 1999 immunosuppressive agent "SERUSEPUTO" released
  • 2000 Release of an antiemetic drug developed to combat the side effects of chemotherapy
  • 2001 Produced an anti-influenza virus "Tamiflu" (Roche)
  • 2001 Discovered a malignant lymphoma target molecule "RITSUKISAN"
  • 2001 Released "Herceptin," a novel breast cancer therapeutic


Other notable developments

Scientists at Chugai discovered an erythromycin-derived motilin agonist called Mitemcinal (aka GM-611 or 3'-N-dimethyl-11-deoxy-3'-N-isopropyl-12-O-methyl-11-oxo-8,9-didehydroerythromycin.) Mitemcinal was believed to have strong prokinetic properties, similar to its parent molecule, but lack antibiotic properties. Presently, erythromycin is commonly used off-label for gastric motility indications such as Gastroparesis. If Mitemcinal can be shown to be as effective a prokinetic agent, it would represent a significant advance in the GI field as treatment with this drug would not carry the risk of unintentional selection of antibiotic-resistant bacteria.

External links

  • Chugai Pharmaceutical Co., Ltd. [2]
  • The transfer of operations of the Company [1]

References



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