PDK1

Pyruvate dehydrogenase kinase, isozyme 1

Rendering based on PDB 2Q8F.
Identifiers
Symbols PDK1;
External IDs OMIM602524 MGI1926119 HomoloGene20576 GeneCards: PDK1 Gene
EC number 2.7.11.2
RNA expression pattern
PBB GE PDK1 206686 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5163 228026
Ensembl ENSG00000152256 ENSMUSG00000006494
UniProt Q15118 Q3U5E5
RefSeq (mRNA) NM_002610.3 NM_172665.4
RefSeq (protein) NP_002601.1 NP_766253.2
Location (UCSC) Chr 2:
173.42 – 173.49 Mb
Chr 2:
71.71 – 71.74 Mb
PubMed search [1] [2]

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial is an enzyme that in humans is encoded by the PDK1 gene.[1][2] It codes for an isozyme of pyruvate dehydrogenase kinase (PDK).

Pyruvate dehydrogenase (PDH) is a part of a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[3]

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TCACycle_WP78 Go to article Go to article Go to article Go to article search for article Go to article Go to article go to article Go to article search for article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article go to article go to article Go to article Go to article go to article go to article Go to article Go to article go to article go to article go to article go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article go to article
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TCACycle_WP78 Go to article Go to article Go to article Go to article search for article Go to article Go to article go to article Go to article search for article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article go to article go to article Go to article Go to article go to article go to article Go to article Go to article go to article go to article go to article go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article Go to article go to article
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Citric_acid_cycle edit

References

  1. ^ Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Jan 1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". J Biol Chem 270 (48): 28989–94. doi:10.1074/jbc.270.48.28989. PMID 7499431. 
  2. ^ a b "Entrez Gene: PDK1 pyruvate dehydrogenase kinase, isozyme 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5163. 
  3. ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". http://www.wikipathways.org/index.php/Pathway:WP78. 

Further reading




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