width = 200
IUPAC_name = 5- [("E")-2-bromoethenyl] -1- [(2"R",3"S",4"S",5"R")-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl] pyrimidine-2,4-dione
synonyms = BV-araU,Bromovinyl araU,5-Bromovinyl-araU
CAS_number = 77181-69-2
ATC_prefix = J05
ATC_suffix = AB15
PubChem = 5282192
C=11 | H=13 | Br=1 | N=2 | O=6
molecular_weight = 349.14 g/mol
metabolism = Viral thymidine kinase
routes_of_administration = oral
Sorivudine (INN) chemical name (E)-5-(2-Bromovinyl)- 1β-D-arabinofuranosyluracil, is a
thymine analogue antiviral drug, marketed under trade names such as Usevir ( Nippon Shoji,Eisai) and Brovavir (BMS).
*First-line treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
*Superior gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted as urine.
Mechanism of action
*Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA, to inhibit viral DNA replication of DNA polymerase to make it fail to inhibit viral growth.
Sorivudine is active against most species in the
Herpes simplex virustype I (HSV-1)
Varicella zoster virus(VZV)
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