Epoxide hydrolase 1, microsomal (xenobiotic), also known as EPHX1, is a human gene.cite web | title = Entrez Gene: EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2052| accessdate = ]

section_title =
summary_text = Epoxide hydrolase plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons.cite web | title = Entrez Gene: EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2052| accessdate = ]


Further reading

citations =
*cite journal | author=Seidegård J, Ekström G |title=The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics. |journal=Environ. Health Perspect. |volume=105 Suppl 4 |issue= |pages= 791–9 |year= 1997 |pmid= 9255563 |doi=
*cite journal | author=Wormhoudt LW, Commandeur JN, Vermeulen NP |title=Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. |journal=Crit. Rev. Toxicol. |volume=29 |issue= 1 |pages= 59–124 |year= 1999 |pmid= 10066160 |doi=
*cite journal | author=Wilson NM, Omiecinski CJ |title=Xenobiotic microsomal epoxide hydrolase: 5' sequence of the human gene. |journal=Biochim. Biophys. Acta |volume=1008 |issue= 3 |pages= 357–8 |year= 1989 |pmid= 2758034 |doi=
*cite journal | author=Strickler SM, Dansky LV, Miller MA, "et al." |title=Genetic predisposition to phenytoin-induced birth defects. |journal=Lancet |volume=2 |issue= 8458 |pages= 746–9 |year= 1985 |pmid= 2864485 |doi=
*cite journal | author=Skoda RC, Demierre A, McBride OW, "et al." |title=Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization. |journal=J. Biol. Chem. |volume=263 |issue= 3 |pages= 1549–54 |year= 1988 |pmid= 2891713 |doi=
*cite journal | author=Jackson MR, Craft JA, Burchell B |title=Nucleotide and deduced amino acid sequence of human liver microsomal epoxide hydrolase. |journal=Nucleic Acids Res. |volume=15 |issue= 17 |pages= 7188 |year= 1987 |pmid= 3502697 |doi=
*cite journal | author=Hassett C, Aicher L, Sidhu JS, Omiecinski CJ |title=Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. |journal=Hum. Mol. Genet. |volume=3 |issue= 3 |pages= 421–8 |year= 1994 |pmid= 7516776 |doi=
*cite journal | author=Hassett C, Robinson KB, Beck NB, Omiecinski CJ |title=The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization. |journal=Genomics |volume=23 |issue= 2 |pages= 433–42 |year= 1995 |pmid= 7835893 |doi= 10.1006/geno.1994.1520
*cite journal | author=McGlynn KA, Rosvold EA, Lustbader ED, "et al." |title=Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 2384–7 |year= 1995 |pmid= 7892276 |doi=
*cite journal | author=Gaedigk A, Spielberg SP, Grant DM |title=Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions. |journal=Pharmacogenetics |volume=4 |issue= 3 |pages= 142–53 |year= 1994 |pmid= 7920694 |doi=
*cite journal | author=Hartsfield JK, Sutcliffe MJ, Everett ET, "et al." |title=Assignment1 of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 44–5 |year= 1999 |pmid= 9925921 |doi=
*cite journal | author=Krovat BC, Tracy JH, Omiecinski CJ |title=Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. |journal=Toxicol. Sci. |volume=55 |issue= 2 |pages= 352–60 |year= 2000 |pmid= 10828267 |doi=
*cite journal | author=Hattori N, Fujiwara H, Maeda M, "et al." |title=Epoxide hydrolase affects estrogen production in the human ovary. |journal=Endocrinology |volume=141 |issue= 9 |pages= 3353–65 |year= 2000 |pmid= 10965908 |doi=
*cite journal | author=Belmahdi F, Chevalier D, Lo-Guidice JM, "et al." |title=Identification of 6 new polymorphisms, g.11177G>A, g.14622C>T (R49C), g.17540T>C, g.17639T>C, g.30929T>C, g.31074G>A (R454Q), in the human microsomal epoxide hydrolase gene (EPHX1) in a French population. |journal=Hum. Mutat. |volume=16 |issue= 5 |pages= 450 |year= 2000 |pmid= 11058921 |doi= 10.1002/1098-1004(200011)16:5<450::AID-HUMU28>3.0.CO;2-1 |doilabel=10.1002/1098-1004(200011)16:5450::AID-HUMU283.0.CO;2-1
*cite journal | author=Zusterzeel PL, Peters WH, Visser W, "et al." |title=A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. |journal=J. Med. Genet. |volume=38 |issue= 4 |pages= 234–7 |year= 2001 |pmid= 11283205 |doi=
*cite journal | author=Sarmanová J, Benesová K, Gut I, "et al." |title=Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas. |journal=Hum. Mol. Genet. |volume=10 |issue= 12 |pages= 1265–73 |year= 2001 |pmid= 11406608 |doi=
*cite journal | author=Farin FM, Janssen P, Quigley S, "et al." |title=Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. |journal=Pharmacogenetics |volume=11 |issue= 8 |pages= 703–8 |year= 2002 |pmid= 11692079 |doi=
*cite journal | author=Coller JK, Fritz P, Zanger UM, "et al." |title=Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours. |journal=Histochem. J. |volume=33 |issue= 6 |pages= 329–36 |year= 2002 |pmid= 11758809 |doi=

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  • Epoxide hydrolase — protein Name= epoxide hydrolase 1, microsomal (xenobiotic) caption= width= HGNCid=3401 Symbol=EPHX1 AltSymbols=EPHX EntrezGene=2052 OMIM=132810 RefSeq=NM 000120 UniProt=P07099 PDB= ECnumber= Chromosome=1 Arm=q Band=42.1… …   Wikipedia

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