2β-Propanoyl-3β-(4-tolyl)-tropane

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IUPAC_name = 2β-Propanoyl-3β-(4-tolyl)-tropane



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C=18 | H=25 | N=1 | O=1
molecular_weight = 271.396
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2β-Propanoyl-3β-(4-tolyl)-tropane also known as WF-11 or PTT is a cocaine analogue 20 times more potent than cocaine at binding to the dopamine transporter with increased selectivity for the norepinephrine transporters. It also shows marked increase in metabolic stability. In contrast to the findings of cocaine effects, WF-11 has been shown to produce a uniform downregulation of TH protein and activity gene expression with a regimen of use. cite journal
url = http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T63-41JM8RB-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9dfa759f0130f9a4f404c4732edd1741
title = ScienceDirect - Drug and Alcohol Dependence : A cocaine analog, 2β-propanoyl-3β-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway
accessdate=2008-01-11
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journal = Drug and Alcohol Dependence
volume = 61
issue = 1
year = 2000
pages = 15–21
doi = 10.1016/S0376-8716(00)00119-8
author = Willard M. Freeman, George J. Yohrling, James B. Daunais, Lynda Gioia, Stephanie L. Hart, Linda J. Porrino, Huw M. L. Davies and Kent E. Vran
]

References

ee also

List of cocaine analogues


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