3 DPF2


DPF2

D4, zinc and double PHD fingers family 2
Identifiers
Symbols DPF2; MGC10180; REQ; UBID4; ubi-d4
External IDs OMIM601671 MGI109529 HomoloGene21265 GeneCards: DPF2 Gene
RNA expression pattern
PBB GE DPF2 202116 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5977 19708
Ensembl ENSG00000133884 ENSMUSG00000024826
UniProt Q92785 Q3UKV4
RefSeq (mRNA) NM_006268 NM_011262.4
RefSeq (protein) NP_006259 NP_035392.1
Location (UCSC) Chr 11:
65.1 – 65.12 Mb
Chr 19:
5.9 – 5.91 Mb
PubMed search [1] [2]

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.[1][2]

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.[2]

References

  1. ^ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. 
  2. ^ a b "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5977. 

Further reading

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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