3 DPF2


D4, zinc and double PHD fingers family 2
Symbols DPF2; MGC10180; REQ; UBID4; ubi-d4
External IDs OMIM601671 MGI109529 HomoloGene21265 GeneCards: DPF2 Gene
RNA expression pattern
PBB GE DPF2 202116 at tn.png
More reference expression data
Species Human Mouse
Entrez 5977 19708
Ensembl ENSG00000133884 ENSMUSG00000024826
UniProt Q92785 Q3UKV4
RefSeq (mRNA) NM_006268 NM_011262.4
RefSeq (protein) NP_006259 NP_035392.1
Location (UCSC) Chr 11:
65.1 – 65.12 Mb
Chr 19:
5.9 – 5.91 Mb
PubMed search [1] [2]

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.[1][2]

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.[2]


  1. ^ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. 
  2. ^ a b "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5977. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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