PATZ1

POZ (BTB) and AT hook containing zinc finger 1

Rendering based on PDB 2EPP.
Identifiers
Symbols PATZ1; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG; dJ400N23
External IDs OMIM605165 MGI1891832 HomoloGene8636 GeneCards: PATZ1 Gene
RNA expression pattern
PBB GE PATZ1 209494 s at tn.png
PBB GE PATZ1 211392 s at tn.png
PBB GE PATZ1 209431 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23598 56218
Ensembl ENSG00000100105 ENSMUSG00000020453
UniProt Q9HBE1 n/a
RefSeq (mRNA) NM_014323.2 NM_019574.2
RefSeq (protein) NP_055138.2 NP_062520.1
Location (UCSC) Chr 22:
31.72 – 31.74 Mb
Chr 11:
3.19 – 3.21 Mb
PubMed search [1] [2]

POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.[1][2][3][4]

The protein encoded by this gene contains an AT-hook DNA binding motif, which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.[4]

Interactions

PATZ1 has been shown to interact with RNF4,[5][6] Microphthalmia-associated transcription factor[7] and Androgen receptor.[6]

References

  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  2. ^ Fedele M, Franco R, Salvatore G, Paronetto MP, Barbagallo F, Pero R, Chiariotti L, Sette C, Tramontano D, Chieffi G, Fusco A, Chieffi P (Apr 2008). "PATZ1 gene has a critical role in the spermatogenesis and testicular tumours". J Pathol 215 (1): 39–47. doi:10.1002/path.2323. PMID 18241078. 
  3. ^ Tian X, Sun D, Zhang Y, Zhao S, Xiong H, Fang J (Apr 2008). "Zinc finger protein 278, a potential oncogene in human colorectal cancer". Acta Biochim Biophys Sin (Shanghai) 40 (4): 289–96. doi:10.1111/j.1745-7270.2008.00405.x. PMID 18401526. 
  4. ^ a b "Entrez Gene: PATZ1 POZ (BTB) and AT hook containing zinc finger 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23598. 
  5. ^ Fedele, M; Benvenuto G, Pero R, Majello B, Battista S, Lembo F, Vollono E, Day P M, Santoro M, Lania L, Bruni C B, Fusco A, Chiariotti L (Mar. 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". J. Biol. Chem. (UNITED STATES) 275 (11): 7894–901. doi:10.1074/jbc.275.11.7894. ISSN 0021-9258. PMID 10713105. 
  6. ^ a b Pero, Raffaela; Lembo Francesca, Palmieri Emiliano Antonio, Vitiello Carmen, Fedele Monica, Fusco Alfredo, Bruni Carmelo Bruno, Chiariotti Lorenzo (Feb. 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". J. Biol. Chem. (United States) 277 (5): 3280–5. doi:10.1074/jbc.M109491200. ISSN 0021-9258. PMID 11719514. 
  7. ^ Morii, Eiichi; Oboki Keisuke, Kataoka Tatsuki R, Igarashi Kazuhiko, Kitamura Yukihiko (Mar. 2002). "Interaction and cooperation of mi transcription factor (MITF) and myc-associated zinc-finger protein-related factor (MAZR) for transcription of mouse mast cell protease 6 gene". J. Biol. Chem. (United States) 277 (10): 8566–71. doi:10.1074/jbc.M110392200. ISSN 0021-9258. PMID 11751862. 

Further reading




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Look at other dictionaries:

  • Androgen receptor — Structure of the ligand binding domain of the androgen receptor (rainbow cartoon) complexed with testosterone (white sticks).[1] …   Wikipedia

  • Microphthalmia-associated transcription factor — Identifiers Symbols MITF; MI; WS2; WS2A; bHLHe32 External IDs …   Wikipedia

  • RNF4 — Ring finger protein 4, also known as RNF4, is a human gene.cite web | title = Entrez Gene: RNF4 ring finger protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6047| accessdate = ] The protein encoded …   Wikipedia

  • Factor de transcripción asociado con microftalmia — HUGO 7105 Símbolo MITF Símbolos alt. WS2A …   Wikipedia Español

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