Phosphodiesterase 9A

PDB rendering based on 2hd1.
Symbols PDE9A; FLJ90181; HSPDE9A2
External IDs OMIM602973 MGI1277179 HomoloGene113565 GeneCards: PDE9A Gene
EC number
RNA expression pattern
PBB GE PDE9A 205593 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5152 18585
Ensembl ENSG00000160191 ENSMUSG00000041119
UniProt O76083 Q3THT7
RefSeq (mRNA) NM_001001567.1 NM_008804
RefSeq (protein) NP_001001567.1 NP_032830
Location (UCSC) Chr 21:
44.07 – 44.2 Mb
Chr 17:
31.52 – 31.61 Mb
PubMed search [1] [2]

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A is an enzyme that in humans is encoded by the PDE9A gene.[1][2]

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene.[2]


  1. ^ Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase". J Biol Chem 273 (25): 15559–64. doi:10.1074/jbc.273.25.15559. PMID 9624146. 
  2. ^ a b "Entrez Gene: PDE9A phosphodiesterase 9A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5152. 

Further reading

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