CMAS (gene)

Cytidine monophosphate N-acetylneuraminic acid synthetase, also known as CMAS, is a human gene.cite web | title = Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase| url =| accessdate = ]

section_title =
summary_text = The enzyme encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.cite web | title = Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Münster AK, Eckhardt M, Potvin B, "et al." |title=Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9140–5 |year= 1998 |pmid= 9689047 |doi=
*cite journal | author=Angata T, Varki NM, Varki A |title=A second uniquely human mutation affecting sialic acid biology. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 40282–7 |year= 2001 |pmid= 11546777 |doi= 10.1074/jbc.M105926200
*cite journal | author=Lawrence SM, Huddleston KA, Tomiya N, "et al." |title=Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells. |journal=Glycoconj. J. |volume=18 |issue= 3 |pages= 205–13 |year= 2002 |pmid= 11602804 |doi=
*cite journal | author=Munster AK, Weinhold B, Gotza B, "et al." |title=Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19688–96 |year= 2002 |pmid= 11893746 |doi= 10.1074/jbc.M201093200
*cite journal | author=Kutsenko AS, Gizatullin RZ, Al-Amin AN, "et al." |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163–70 |year= 2002 |pmid= 12136098 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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