RICTOR

Rapamycin-insensitive companion of mTOR, also known as RICTOR, is a human gene.cite web | title = Entrez Gene: RICTOR rapamycin-insensitive companion of mTOR| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=253260| accessdate = ]

PBB_Summary
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summary_text = RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004). [supplied by OMIM] cite web | title = Entrez Gene: RICTOR rapamycin-insensitive companion of mTOR| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=253260| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cohen D, Scribner R, Clark J, Cory D |title=The potential role of custody facilities in controlling sexually transmitted diseases. |journal=American journal of public health |volume=82 |issue= 4 |pages= 552–6 |year= 1992 |pmid= 1546771 |doi=
*cite journal | author=Ohara O, Nagase T, Mitsui G, "et al." |title=Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. |journal=DNA Res. |volume=9 |issue= 2 |pages= 47–57 |year= 2003 |pmid= 12056414 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Sarbassov DD, Ali SM, Kim DH, "et al." |title=Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. |journal=Curr. Biol. |volume=14 |issue= 14 |pages= 1296–302 |year= 2004 |pmid= 15268862 |doi= 10.1016/j.cub.2004.06.054
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Jacinto E, Loewith R, Schmidt A, "et al." |title=Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. |journal=Nat. Cell Biol. |volume=6 |issue= 11 |pages= 1122–8 |year= 2004 |pmid= 15467718 |doi= 10.1038/ncb1183
*cite journal | author=Sarbassov DD, Guertin DA, Ali SM, Sabatini DM |title=Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. |journal=Science |volume=307 |issue= 5712 |pages= 1098–101 |year= 2005 |pmid= 15718470 |doi= 10.1126/science.1106148
*cite journal | author=Kudchodkar SB, Yu Y, Maguire TG, Alwine JC |title=Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 38 |pages= 14182–7 |year= 2006 |pmid= 16959881 |doi= 10.1073/pnas.0605825103
*cite journal | author=Jacinto E, Facchinetti V, Liu D, "et al." |title=SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. |journal=Cell |volume=127 |issue= 1 |pages= 125–37 |year= 2006 |pmid= 16962653 |doi= 10.1016/j.cell.2006.08.033
*cite journal | author=Yang Q, Inoki K, Ikenoue T, Guan KL |title=Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. |journal=Genes Dev. |volume=20 |issue= 20 |pages= 2820–32 |year= 2006 |pmid= 17043309 |doi= 10.1101/gad.1461206
*cite journal | author=Fuchs BC, Finger RE, Onan MC, Bode BP |title=ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells. |journal=Am. J. Physiol., Cell Physiol. |volume=293 |issue= 1 |pages= C55–63 |year= 2007 |pmid= 17329400 |doi= 10.1152/ajpcell.00330.2006
*cite journal | author=Pearce LR, Huang X, Boudeau J, "et al." |title=Identification of Protor as a novel Rictor-binding component of mTOR complex-2. |journal=Biochem. J. |volume=405 |issue= 3 |pages= 513–22 |year= 2007 |pmid= 17461779 |doi= 10.1042/BJ20070540

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