SENP6


SENP6

SUMO1/sentrin specific peptidase 6, also known as SENP6, is a human gene.cite web | title = Entrez Gene: SENP6 SUMO1/sentrin specific peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26054| accessdate = ]

PBB_Summary
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summary_text = Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000). [supplied by OMIM] cite web | title = Entrez Gene: SENP6 SUMO1/sentrin specific peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26054| accessdate = ]

References

Further reading

*cite journal | author=Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS. |title=Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs.|journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26217–24 |year= 2007 |pmid= 17591783 |doi=10.1074/jbc.M702444200
*cite journal | author=Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS. |title=Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family. |journal=Biochem J. |volume=409 |issue= 2 |pages= 461–9 |year= 2008 |pmid= 17916063 |doi=10.1042/BJ20070940 PBB_Further_reading
citations =
*cite journal | author=Yeh ET, Gong L, Kamitani T |title=Ubiquitin-like proteins: new wines in new bottles. |journal=Gene |volume=248 |issue= 1-2 |pages= 1–14 |year= 2000 |pmid= 10806345 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=
*cite journal | author=Kim KI, Baek SH, Jeon YJ, "et al." |title=A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14102–6 |year= 2000 |pmid= 10799485 |doi=
*cite journal | author=Goodson ML, Hong Y, Rogers R, "et al." |title=Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 18513–8 |year= 2001 |pmid= 11278381 |doi= 10.1074/jbc.M008066200
*cite journal | author=Tojo M, Matsuzaki K, Minami T, "et al." |title=The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46576–85 |year= 2003 |pmid= 12354770 |doi= 10.1074/jbc.M205987200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bailey D, O'Hare P |title=Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 692–703 |year= 2004 |pmid= 14563852 |doi= 10.1074/jbc.M306195200
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Choi SJ, Chung SS, Rho EJ, "et al." |title=Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30669–77 |year= 2006 |pmid= 16912044 |doi= 10.1074/jbc.M604033200
*cite journal | author=Mukhopadhyay D, Ayaydin F, Kolli N, "et al." |title=SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. |journal=J. Cell Biol. |volume=174 |issue= 7 |pages= 939–49 |year= 2006 |pmid= 17000875 |doi= 10.1083/jcb.200510103
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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