HLA-DQA2

Major histocompatibility complex, class II, DQ alpha 2, also known as HLA-DQA2, is a human gene.cite web | title = Entrez Gene: HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3118| accessdate = ]

The protein encoded by this gene is expressed, but unlike HLA-DQA1, it apparently unable to heterodimerize with HLA class II beta chain paralogues.cite journal | author = Rudy GB, Lew AM | title = The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells | journal = J. Immunol. | volume = 158 | issue = 5 | pages = 2116–25 | year = 1997 | month = March | pmid = 9036956 | doi = | url = http://www.jimmunol.org/cgi/content/abstract/158/5/2116 | issn = ] The low level of HLA-DQA2 expression is apparently due to impaired transcription factor binding to the HLA-DQA2 gene promoter.cite journal | author = Indovina P, Megiorni F, Fontemaggi G, Coni P, Mora B, Mazzilli MC | title = Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions | journal = Hum. Immunol. | volume = 62 | issue = 5 | pages = 504–8 | year = 2001 | month = May | pmid = 11334674 | doi = 10.1016/S0198-8859(01)00236-1 | url = | issn = ]

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References

Further reading

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citations =
*cite journal | author=Marsh SG, Bodmer JG |title=HLA class II nucleotide sequences, 1992. |journal=Tissue Antigens |volume=40 |issue= 5 |pages= 229–43 |year= 1993 |pmid= 1362295 |doi=
*cite journal | author=Kenter M, Otting N, Anholts J, "et al." |title=Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles. |journal=Immunogenetics |volume=36 |issue= 2 |pages= 71–8 |year= 1992 |pmid= 1612647 |doi=
*cite journal | author=Piatier-Tonneau D, Gastinel LN, Amblard F, "et al." |title=Interaction of CD4 with HLA class II antigens and HIV gp120. |journal=Immunogenetics |volume=34 |issue= 2 |pages= 121–8 |year= 1991 |pmid= 1869305 |doi=
*cite journal | author=Rosenstein Y, Burakoff SJ, Herrmann SH |title=HIV-gp120 can block CD4-class II MHC-mediated adhesion. |journal=J. Immunol. |volume=144 |issue= 2 |pages= 526–31 |year= 1990 |pmid= 1967269 |doi=
*cite journal | author=Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ |title=Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 9052–6 |year= 1991 |pmid= 1978941 |doi=
*cite journal | author=Gyllensten UB, Erlich HA |title=Ancient roots for polymorphism at the HLA-DQ alpha locus in primates. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 24 |pages= 9986–90 |year= 1990 |pmid= 2513578 |doi=
*cite journal | author=Clayton LK, Sieh M, Pious DA, Reinherz EL |title=Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. |journal=Nature |volume=339 |issue= 6225 |pages= 548–51 |year= 1989 |pmid= 2543930 |doi= 10.1038/339548a0
*cite journal | author=Diamond DC, Sleckman BP, Gregory T, "et al." |title=Inhibition of CD4+ T cell function by the HIV envelope protein, gp120. |journal=J. Immunol. |volume=141 |issue= 11 |pages= 3715–7 |year= 1988 |pmid= 2846691 |doi=
*cite journal | author=Jonsson AK, Hyldig-Nielsen JJ, Servenius B, "et al." |title=Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes. |journal=J. Biol. Chem. |volume=262 |issue= 18 |pages= 8767–77 |year= 1987 |pmid= 3036828 |doi=
*cite journal | author=Horn GT, Bugawan TL, Long CM, "et al." |title=Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals. |journal=Hum. Immunol. |volume=21 |issue= 4 |pages= 249–63 |year= 1988 |pmid= 3372263 |doi=
*cite journal | author=Andrieu JM, Even P, Venet A |title=AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications. |journal=AIDS research |volume=2 |issue= 3 |pages= 163–74 |year= 1986 |pmid= 3489470 |doi=
*cite journal | author=Auffray C, Lillie JW, Korman AJ, "et al." |title=Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector. |journal=Immunogenetics |volume=26 |issue= 1-2 |pages= 63–73 |year= 1987 |pmid= 3610256 |doi=
*cite journal | author=Trowsdale J, Lee J, Carey J, "et al." |title=Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=80 |issue= 7 |pages= 1972–6 |year= 1983 |pmid= 6300884 |doi=
*cite journal | author=Auffray C, Lillie JW, Arnot D, "et al." |title=Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. |journal=Nature |volume=308 |issue= 5957 |pages= 327–33 |year= 1984 |pmid= 6584734 |doi=
*cite journal | author=Houlgatte R, Scarmato P, el Marhomy S, "et al." |title=HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4. |journal=J. Immunol. |volume=152 |issue= 9 |pages= 4475–88 |year= 1994 |pmid= 7512597 |doi=
*cite journal | author=Chirmule N, McCloskey TW, Hu R, "et al." |title=HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71). |journal=J. Immunol. |volume=155 |issue= 2 |pages= 917–24 |year= 1995 |pmid= 7541827 |doi=
*cite journal | author=Rowell JF, Stanhope PE, Siliciano RF |title=Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC. |journal=J. Immunol. |volume=155 |issue= 1 |pages= 473–88 |year= 1995 |pmid= 7602119 |doi=
*cite journal | author=Rudy G, Lew AM |title=Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer. |journal=Hum. Immunol. |volume=39 |issue= 3 |pages= 225–9 |year= 1994 |pmid= 8026991 |doi=
*cite journal | author=Chen YH, Böck G, Vornhagen R, "et al." |title=HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41. |journal=Mol. Immunol. |volume=31 |issue= 13 |pages= 977–82 |year= 1994 |pmid= 8084338 |doi=
*cite journal | author=Chirmule N, Wang XP, Hu R, "et al." |title=Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help. |journal=Cell. Immunol. |volume=155 |issue= 1 |pages= 169–82 |year= 1994 |pmid= 8168144 |doi= 10.1006/cimm.1994.1110

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