Alpha-4 beta-2 nicotinic receptor

The alpha-4 beta-2 nicotinic receptor ((α4)2(β2)3) is a type of nicotinic acetylcholine receptor, consisting of α4 and β2 subunits Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 138. ] .

It is located in the brain, where activation yields post- and presynaptic excitation, mainly by increased Na+ and K+ permeability.

Agonists

Nicotinic agonists for this receptor include:
*nicotine
*epibatidine
*acetylcholine
*cytisine
*ABT-089
*ABT-418
*dianicline
*ispronicline
*rivanicline
*tebanicline
*varenicline

Antagonists

*mecamylamine
*methylaconitine
*α-conotoxin

References


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