HIR histone cell cycle regulation defective homolog A (S. cerevisiae), also known as HIRA, is a human gene.cite web | title = Entrez Gene: HIRA HIR histone cell cycle regulation defective homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7290| accessdate = ]

section_title =
summary_text = The specific function of this gene has yet to be determined; however, it has been speculated to play a role in transcription regulation and/or chromatin and histone metabolism. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. This gene is mapped to 22q11.21, centromeric to COMT.cite web | title = Entrez Gene: HIRA HIR histone cell cycle regulation defective homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7290| accessdate = ]


Further reading

citations =
*cite journal | author=Lamour V, Lécluse Y, Desmaze C, "et al." |title=A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region. |journal=Hum. Mol. Genet. |volume=4 |issue= 5 |pages= 791–9 |year= 1995 |pmid= 7633437 |doi=
*cite journal | author=Halford S, Wadey R, Roberts C, "et al." |title=Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease. |journal=Hum. Mol. Genet. |volume=2 |issue= 12 |pages= 2099–107 |year= 1994 |pmid= 8111380 |doi=
*cite journal | author=Lorain S, Demczuk S, Lamour V, "et al." |title=Structural Organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22. |journal=Genome Res. |volume=6 |issue= 1 |pages= 43–50 |year= 1996 |pmid= 8681138 |doi=
*cite journal | author=Llevadot R, Scambler P, Estivill X, Pritchard M |title=Genomic organization of TUPLE1/HIRA: a gene implicated in DiGeorge syndrome. |journal=Mamm. Genome |volume=7 |issue= 12 |pages= 911–4 |year= 1997 |pmid= 8995764 |doi=
*cite journal | author=Lorain S, Quivy JP, Monier-Gavelle F, "et al." |title=Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5546–56 |year= 1998 |pmid= 9710638 |doi=
*cite journal | author=Magnaghi P, Roberts C, Lorain S, "et al." |title=HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 74–7 |year= 1998 |pmid= 9731536 |doi= 10.1038/1739
*cite journal | author=Hall C, Nelson DM, Ye X, "et al." |title=HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. |journal=Mol. Cell. Biol. |volume=21 |issue= 5 |pages= 1854–65 |year= 2001 |pmid= 11238922 |doi= 10.1128/MCB.21.5.1854-1865.2001
*cite journal | author=Lorain S, Lécluse Y, Scamps C, "et al." |title=Identification of human and mouse HIRA-interacting protein-5 (HIRIP5), two mammalian representatives in a family of phylogenetically conserved proteins with a role in the biogenesis of Fe/S proteins. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 3 |pages= 376–83 |year= 2001 |pmid= 11342215 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gocke CB, Yu H, Kang J |title=Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 5004–12 |year= 2005 |pmid= 15561718 |doi= 10.1074/jbc.M411718200
*cite journal | author=Zhang R, Poustovoitov MV, Ye X, "et al." |title=Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. |journal=Dev. Cell |volume=8 |issue= 1 |pages= 19–30 |year= 2005 |pmid= 15621527 |doi= 10.1016/j.devcel.2004.10.019
*cite journal | author=Ahmad A, Kikuchi H, Takami Y, Nakayama T |title=Different roles of N-terminal and C-terminal halves of HIRA in transcription regulation of cell cycle-related genes that contribute to control of vertebrate cell growth. |journal=J. Biol. Chem. |volume=280 |issue= 37 |pages= 32090–100 |year= 2005 |pmid= 16024922 |doi= 10.1074/jbc.M501426200
*cite journal | author=Tang Y, Poustovoitov MV, Zhao K, "et al." |title=Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 10 |pages= 921–9 |year= 2006 |pmid= 16980972 |doi= 10.1038/nsmb1147
*cite journal | author=Zhang R, Chen W, Adams PD |title=Molecular dissection of formation of senescence-associated heterochromatin foci. |journal=Mol. Cell. Biol. |volume=27 |issue= 6 |pages= 2343–58 |year= 2007 |pmid= 17242207 |doi= 10.1128/MCB.02019-06

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