Ring finger protein 4, also known as RNF4, is a human gene.cite web | title = Entrez Gene: RNF4 ring finger protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6047| accessdate = ]

The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.cite web | title = Entrez Gene: RNF4 ring finger protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6047| accessdate = ]

ee also

* RING finger domain


Further reading

citations =
*cite journal | author=Chiariotti L, Benvenuto G, Fedele M, "et al." |title=Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3. |journal=Genomics |volume=47 |issue= 2 |pages= 258–65 |year= 1998 |pmid= 9479498 |doi= 10.1006/geno.1997.5105
*cite journal | author=Moilanen AM, Poukka H, Karvonen U, "et al." |title=Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5128–39 |year= 1998 |pmid= 9710597 |doi=
*cite journal | author=Hadano S, Ishida Y, Ikeda JE |title=The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. |journal=DNA Res. |volume=5 |issue= 3 |pages= 177–86 |year= 1998 |pmid= 9734812 |doi=
*cite journal | author=Poukka H, Aarnisalo P, Santti H, "et al." |title=Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 571–9 |year= 2000 |pmid= 10617653 |doi=
*cite journal | author=Fedele M, Benvenuto G, Pero R, "et al." |title=A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7894–901 |year= 2000 |pmid= 10713105 |doi=
*cite journal | author=Galili N, Nayak S, Epstein JA, Buck CA |title=Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region. |journal=Dev. Dyn. |volume=218 |issue= 1 |pages= 102–11 |year= 2000 |pmid= 10822263 |doi= 10.1002/(SICI)1097-0177(200005)218:1<102::AID-DVDY9>3.0.CO;2-A |doilabel=10.1002/(SICI)1097-0177(200005)218:1102::AID-DVDY93.0.CO;2-A
*cite journal | author=Lyngsø C, Bouteiller G, Damgaard CK, "et al." |title=Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26144–9 |year= 2000 |pmid= 10849425 |doi= 10.1074/jbc.M003405200
*cite journal | author=Häkli M, Karvonen U, Jänne OA, Palvimo JJ |title=The RING finger protein SNURF is a bifunctional protein possessing DNA binding activity. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23653–60 |year= 2001 |pmid= 11319220 |doi= 10.1074/jbc.M009891200
*cite journal | author=Saville B, Poukka H, Wormke M, "et al." |title=Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2485–97 |year= 2002 |pmid= 11696545 |doi= 10.1074/jbc.M109021200
*cite journal | author=Pero R, Lembo F, Palmieri EA, "et al." |title=PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3280–5 |year= 2002 |pmid= 11719514 |doi= 10.1074/jbc.M109491200
*cite journal | author=Yan W, Hirvonen-Santti SJ, Palvimo JJ, "et al." |title=Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation. |journal=Mech. Dev. |volume=118 |issue= 1-2 |pages= 247–53 |year= 2003 |pmid= 12351196 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pero R, Lembo F, Chieffi P, "et al." |title=Translational regulation of a novel testis-specific RNF4 transcript. |journal=Mol. Reprod. Dev. |volume=66 |issue= 1 |pages= 1–7 |year= 2004 |pmid= 12874792 |doi= 10.1002/mrd.10322
*cite journal | author=Kaiser FJ, Möröy T, Chang GT, "et al." |title=The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38780–5 |year= 2003 |pmid= 12885770 |doi= 10.1074/jbc.M306259200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lin DY, Fang HI, Ma AH, "et al." |title=Negative modulation of androgen receptor transcriptional activity by Daxx. |journal=Mol. Cell. Biol. |volume=24 |issue= 24 |pages= 10529–41 |year= 2004 |pmid= 15572661 |doi= 10.1128/MCB.24.24.10529-10541.2004

External links


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Look at other dictionaries:

  • PATZ1 — POZ (BTB) and AT hook containing zinc finger 1 Rendering based on PDB 2EPP …   Wikipedia

  • Ununoctium — ununseptium ← ununoctium → ununennium Rn ↑ Uuo ↓ (Uho) …   Wikipedia

  • Androgen receptor — Structure of the ligand binding domain of the androgen receptor (rainbow cartoon) complexed with testosterone (white sticks).[1] …   Wikipedia

  • TCF20 — Transcription factor 20 (AR1), also known as TCF20, is a human gene.cite web | title = Entrez Gene: TCF20 transcription factor 20 (AR1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6942| accessdate = ]… …   Wikipedia

  • RING finger domain — Pfam box Symbol = zf C3HC4 Name = Zinc finger, C3HC4 type (RING finger) width = caption = Pfam= PF00097 InterPro= IPR001841 SMART= PROSITE= PDOC00449 SCOP = 1chc TCDB = OPM family= OPM protein= PDB=PDB3|1jm7A:24 64 PDB3|1rmd :290 328 PDB3|1bor… …   Wikipedia

  • Ununoctio — Ununseptio ← Ununoctio → Ununennio Rn …   Wikipedia Español

  • Радон — У этого термина существуют и другие значения, см. Радон (значения). 86 Астат ← Радон → Франций …   Википедия

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