Nudix (nucleoside diphosphate linked moiety X)-type motif 2

PDB rendering based on 1xsa.
Symbols NUDT2; APAH1; MGC10404
External IDs OMIM602852 MGI1913651 HomoloGene896 GeneCards: NUDT2 Gene
EC number
RNA expression pattern
PBB GE NUDT2 218609 s at tn.png
More reference expression data
Species Human Mouse
Entrez 318 66401
Ensembl ENSG00000164978 ENSMUSG00000028443
UniProt P50583 Q3V1C8
RefSeq (mRNA) NM_001161.3 NM_025539.2
RefSeq (protein) NP_001152.1 NP_079815.2
Location (UCSC) Chr 9:
34.33 – 34.34 Mb
Chr 4:
41.41 – 41.43 Mb
PubMed search [1] [2]

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] is an enzyme that in humans is encoded by the NUDT2 gene.[1][2][3]

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified.[3]


  1. ^ Thorne NM, Hankin S, Wilkinson MC, Nunez C, Barraclough R, McLennan AG (Dec 1995). "Human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases". Biochem J 311 ( Pt 3): 717–21. PMC 1136061. PMID 7487923. 
  2. ^ McLennan AG, Flannery AV, Morten JE, Ridanpaa M (Apr 1998). "Chromosomal localization of the human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) gene (APAH1) to 9p13". Genomics 47 (2): 307–9. doi:10.1006/geno.1997.5092. PMID 9479504. 
  3. ^ a b "Entrez Gene: NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2". 

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