Thiothixene

Thiothixene
Systematic (IUPAC) name
(9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
Clinical data
Trade names Navane
AHFS/Drugs.com monograph
MedlinePlus a682867
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral
Pharmacokinetic data
Metabolism Hepatic
Half-life 10-20 hours
Identifiers
CAS number 5591-45-7 YesY
ATC code N05AF04
PubChem CID 941651
IUPHAR ligand 212
DrugBank DB01623
ChemSpider 819430 YesY
UNII 7318FJ13YJ N
ChEMBL CHEMBL1201 YesY
Chemical data
Formula C23H29N3O2S2 
Mol. mass 443.627 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Thiothixene (Navane) is a typical antipsychotic drug of the thioxanthene class used in the treatment of psychoses like schizophrenia. It was introduced on July 24, 1967[1] by Pfizer.[2]

Chemistry

Thiothixene rx.png

See also:

  • J.F. Muren, B.M. Bloom, DE 1470157  (1963).
  • Chas. Pfizer & Co., BE 647066  (1964).
  • Muren, James F.; Bloom, Barry M. (1970). "Thioxanthene psychopharmacological agents. II. 9-(3-aminopropylidene)-N,N-dimethylthioxanthene-2-sulfonamides". Journal of Medicinal Chemistry 13 (1): 17. doi:10.1021/jm00295a005. PMID 5412109.  edit

See also

References