Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F, also known as SEMA3F, is a human gene.cite web | title = Entrez Gene: SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F| url =| accessdate = ]

section_title =
summary_text = The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family. [supplied by OMIM] cite web | title = Entrez Gene: SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM |title=Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. |journal=Nature |volume=376 |issue= 6540 |pages= 509–14 |year= 1995 |pmid= 7637782 |doi= 10.1038/376509a0
*cite journal | author=Kolodkin AL, Matthes DJ, Goodman CS |title=The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. |journal=Cell |volume=75 |issue= 7 |pages= 1389–99 |year= 1994 |pmid= 8269517 |doi=
*cite journal | author=Luo Y, Raible D, Raper JA |title=Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. |journal=Cell |volume=75 |issue= 2 |pages= 217–27 |year= 1993 |pmid= 8402908 |doi=
*cite journal | author=Sekido Y, Bader S, Latif F, "et al." |title=Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 9 |pages= 4120–5 |year= 1996 |pmid= 8633026 |doi=
*cite journal | author=Roche J, Boldog F, Robinson M, "et al." |title=Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. |journal=Oncogene |volume=12 |issue= 6 |pages= 1289–97 |year= 1996 |pmid= 8649831 |doi=
*cite journal | author=Xiang RH, Hensel CH, Garcia DK, "et al." |title=Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer. |journal=Genomics |volume=32 |issue= 1 |pages= 39–48 |year= 1996 |pmid= 8786119 |doi= 10.1006/geno.1996.0074
*cite journal | author=Chen H, He Z, Bagri A, Tessier-Lavigne M |title=Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. |journal=Neuron |volume=21 |issue= 6 |pages= 1283–90 |year= 1999 |pmid= 9883722 |doi=
*cite journal | author=Hirsch E, Hu LJ, Prigent A, "et al." |title=Distribution of semaphorin IV in adult human brain. |journal=Brain Res. |volume=823 |issue= 1-2 |pages= 67–79 |year= 1999 |pmid= 10095013 |doi=
*cite journal | author=Brambilla E, Constantin B, Drabkin H, Roche J |title=Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration. |journal=Am. J. Pathol. |volume=156 |issue= 3 |pages= 939–50 |year= 2000 |pmid= 10702410 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nasarre P, Constantin B, Rouhaud L, "et al." |title=Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading. |journal=Neoplasia |volume=5 |issue= 1 |pages= 83–92 |year= 2003 |pmid= 12659673 |doi=
*cite journal | author=Lantuéjoul S, Constantin B, Drabkin H, "et al." |title=Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines. |journal=J. Pathol. |volume=200 |issue= 3 |pages= 336–47 |year= 2003 |pmid= 12845630 |doi= 10.1002/path.1367
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bielenberg DR, Hida Y, Shimizu A, "et al." |title=Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. |journal=J. Clin. Invest. |volume=114 |issue= 9 |pages= 1260–71 |year= 2004 |pmid= 15520858 |doi= 10.1172/JCI200421378
*cite journal | author=Gu C, Yoshida Y, Livet J, "et al." |title=Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. |journal=Science |volume=307 |issue= 5707 |pages= 265–8 |year= 2005 |pmid= 15550623 |doi= 10.1126/science.1105416
*cite journal | author=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1-3 |pages= 203–8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007
*cite journal | author=Kusy S, Nasarre P, Chan D, "et al." |title=Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells. |journal=Neoplasia |volume=7 |issue= 5 |pages= 457–65 |year= 2005 |pmid= 15967098 |doi=
*cite journal | author=Futamura M, Kamino H, Miyamoto Y, "et al." |title=Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression. |journal=Cancer Res. |volume=67 |issue= 4 |pages= 1451–60 |year= 2007 |pmid= 17308083 |doi= 10.1158/0008-5472.CAN-06-2485
*cite journal | author=Guttmann-Raviv N, Shraga-Heled N, Varshavsky A, "et al." |title=Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis. |journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26294–305 |year= 2007 |pmid= 17569671 |doi= 10.1074/jbc.M609711200
*cite journal | author=Menon L, Mihailescu MR |title=Interactions of the G quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family. |journal=Nucleic Acids Res. |volume=35 |issue= 16 |pages= 5379–92 |year= 2007 |pmid= 17693432 |doi= 10.1093/nar/gkm581

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