BRD4

Bromodomain containing 4, also known as BRD4, is a human gene.cite web | title = Entrez Gene: BRD4 bromodomain containing 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23476| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.cite web | title = Entrez Gene: BRD4 bromodomain containing 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23476| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dey A, Ellenberg J, Farina A, "et al." |title=A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6537–49 |year= 2000 |pmid= 10938129 |doi=
*cite journal | author=French CA, Miyoshi I, Aster JC, "et al." |title=BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). |journal=Am. J. Pathol. |volume=159 |issue= 6 |pages= 1987–92 |year= 2001 |pmid= 11733348 |doi=
*cite journal | author=Maruyama T, Farina A, Dey A, "et al." |title=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6509–20 |year= 2002 |pmid= 12192049 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=French CA, Miyoshi I, Kubonishi I, "et al." |title=BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. |journal=Cancer Res. |volume=63 |issue= 2 |pages= 304–7 |year= 2003 |pmid= 12543779 |doi=
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=You J, Croyle JL, Nishimura A, "et al." |title=Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. |journal=Cell |volume=117 |issue= 3 |pages= 349–60 |year= 2004 |pmid= 15109495 |doi=
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Farina A, Hattori M, Qin J, "et al." |title=Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9059–69 |year= 2004 |pmid= 15456879 |doi= 10.1128/MCB.24.20.9059-9069.2004
*cite journal | author=Baxter MK, McPhillips MG, Ozato K, McBride AA |title=The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4. |journal=J. Virol. |volume=79 |issue= 8 |pages= 4806–18 |year= 2005 |pmid= 15795266 |doi= 10.1128/JVI.79.8.4806-4818.2005
*cite journal | author=Haruki N, Kawaguchi KS, Eichenberger S, "et al." |title=Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro. |journal=J. Med. Genet. |volume=42 |issue= 7 |pages= 558–64 |year= 2006 |pmid= 15994877 |doi= 10.1136/jmg.2004.029686
*cite journal | author=Schweiger MR, You J, Howley PM |title=Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. |journal=J. Virol. |volume=80 |issue= 9 |pages= 4276–85 |year= 2006 |pmid= 16611886 |doi= 10.1128/JVI.80.9.4276-4285.2006
*cite journal | author=Wu SY, Lee AY, Hou SY, "et al." |title=Brd4 links chromatin targeting to HPV transcriptional silencing. |journal=Genes Dev. |volume=20 |issue= 17 |pages= 2383–96 |year= 2006 |pmid= 16921027 |doi= 10.1101/gad.1448206
*cite journal | author=You J, Srinivasan V, Denis GV, "et al." |title=Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. |journal=J. Virol. |volume=80 |issue= 18 |pages= 8909–19 |year= 2006 |pmid= 16940503 |doi= 10.1128/JVI.00502-06
*cite journal | author=Sénéchal H, Poirier GG, Coulombe B, "et al." |title=Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4. |journal=Virology |volume=358 |issue= 1 |pages= 10–7 |year= 2007 |pmid= 17023018 |doi= 10.1016/j.virol.2006.08.035
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Abbate EA, Voitenleitner C, Botchan MR |title=Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association. |journal=Mol. Cell |volume=24 |issue= 6 |pages= 877–89 |year= 2007 |pmid= 17189190 |doi= 10.1016/j.molcel.2006.11.002
*cite journal | author=Schweiger MR, Ottinger M, You J, Howley PM |title=Brd4-independent transcriptional repression function of the papillomavirus e2 proteins. |journal=J. Virol. |volume=81 |issue= 18 |pages= 9612–22 |year= 2007 |pmid= 17626100 |doi= 10.1128/JVI.00447-07
*cite journal | author=Bisgrove DA, Mahmoudi T, Henklein P, Verdin E |title=Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 34 |pages= 13690–5 |year= 2007 |pmid= 17690245 |doi= 10.1073/pnas.0705053104

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