Basal cell adhesion molecule (Lutheran blood group), also known as BCAM, is a human gene.cite web | title = Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4059| accessdate = ] BCAM has also recently been designated CD239 (cluster of differentiation 239).

section_title =
summary_text = Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4059| accessdate = ]


Further reading

citations =
*cite journal | author=Eyler CE, Telen MJ |title=The Lutheran glycoprotein: a multifunctional adhesion receptor. |journal=Transfusion |volume=46 |issue= 4 |pages= 668–77 |year= 2006 |pmid= 16584446 |doi= 10.1111/j.1537-2995.2006.00779.x
*cite journal | author=Lewis M, Kaita H, Coghlan G, "et al." |title=The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man. |journal=Ann. Hum. Genet. |volume=52 |issue= Pt 2 |pages= 137–44 |year= 1989 |pmid= 2907851 |doi=
*cite journal | author=Parsons SF, Mallinson G, Holmes CH, "et al." |title=The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 12 |pages= 5496–500 |year= 1995 |pmid= 7777537 |doi=
*cite journal | author=Campbell IG, Foulkes WD, Senger G, "et al." |title=Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. |journal=Cancer Res. |volume=54 |issue= 22 |pages= 5761–5 |year= 1994 |pmid= 7954395 |doi=
*cite journal | author=Rahuel C, Le Van Kim C, Mattei MG, "et al." |title=A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein. |journal=Blood |volume=88 |issue= 5 |pages= 1865–72 |year= 1996 |pmid= 8781446 |doi=
*cite journal | author=Parsons SF, Mallinson G, Daniels GL, "et al." |title=Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms. |journal=Blood |volume=89 |issue= 11 |pages= 4219–25 |year= 1997 |pmid= 9166867 |doi=
*cite journal | author=El Nemer W, Rahuel C, Colin Y, "et al." |title=Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism. |journal=Blood |volume=89 |issue= 12 |pages= 4608–16 |year= 1997 |pmid= 9192786 |doi=
*cite journal | author=Parsons SF, Lee G, Spring FA, "et al." |title=Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity. |journal=Blood |volume=97 |issue= 1 |pages= 312–20 |year= 2001 |pmid= 11133776 |doi=
*cite journal | author=El Nemer W, Gane P, Colin Y, "et al." |title=Characterization of the laminin binding domains of the Lutheran blood group glycoprotein. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23757–62 |year= 2001 |pmid= 11319237 |doi= 10.1074/jbc.M102978200
*cite journal | author=Kikkawa Y, Moulson CL, Virtanen I, Miner JH |title=Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 44864–9 |year= 2003 |pmid= 12244066 |doi= 10.1074/jbc.M208731200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shin BK, Wang H, Yim AM, "et al." |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607–16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200
*cite journal | author=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660–6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827
*cite journal | author=Crew VK, Green C, Daniels G |title=Molecular bases of the antigens of the Lutheran blood group system. |journal=Transfusion |volume=43 |issue= 12 |pages= 1729–37 |year= 2004 |pmid= 14641871 |doi=
*cite journal | author=Zen Q, Batchvarova M, Twyman CA, "et al." |title=B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. |journal=Am. J. Hematol. |volume=75 |issue= 2 |pages= 63–72 |year= 2004 |pmid= 14755370 |doi= 10.1002/ajh.10442
*cite journal | author=Kroviarski Y, El Nemer W, Gane P, "et al." |title=Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin. |journal=Br. J. Haematol. |volume=126 |issue= 2 |pages= 255–64 |year= 2004 |pmid= 15238148 |doi= 10.1111/j.1365-2141.2004.05010.x
*cite journal | author=Drewniok C, Wienrich BG, Schön M, "et al." |title=Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. |journal=Arch. Dermatol. Res. |volume=296 |issue= 2 |pages= 59–66 |year= 2005 |pmid= 15278364 |doi= 10.1007/s00403-004-0481-4
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Cheng J, Kapranov P, Drenkow J, "et al." |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625
*cite journal | author=Vainionpää N, Kikkawa Y, Lounatmaa K, "et al." |title=Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. |journal=Am. J. Physiol., Cell Physiol. |volume=290 |issue= 3 |pages= C764–75 |year= 2006 |pmid= 16236823 |doi= 10.1152/ajpcell.00285.2005

External links


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