WW domain containing E3 ubiquitin protein ligase 1, also known as WWP1, is a human gene.cite web | title = Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11059| accessdate = ]

section_title =
summary_text = WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.cite web | title = Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11059| accessdate = ]


Further reading

citations =
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*cite journal | author=Pirozzi G, McConnell SJ, Uveges AJ, "et al." |title=Identification of novel human WW domain-containing proteins by cloning of ligand targets. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14611–6 |year= 1997 |pmid= 9169421 |doi=
*cite journal | author=Wood JD, Yuan J, Margolis RL, "et al." |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149–60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677
*cite journal | author=Mosser EA, Kasanov JD, Forsberg EC, "et al." |title=Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains. |journal=Biochemistry |volume=37 |issue= 39 |pages= 13686–95 |year= 1998 |pmid= 9753456 |doi= 10.1021/bi981310l
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Conkright MD, Wani MA, Lingrel JB |title=Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29299–306 |year= 2001 |pmid= 11375995 |doi= 10.1074/jbc.M103670200
*cite journal | author=Flasza M, Gorman P, Roylance R, "et al." |title=Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 1 |pages= 431–7 |year= 2002 |pmid= 11779188 |doi= 10.1006/bbrc.2001.6206
*cite journal | author=Galinier R, Gout E, Lortat-Jacob H, "et al." |title=Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. |journal=Biochemistry |volume=41 |issue= 48 |pages= 14299–305 |year= 2003 |pmid= 12450395 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Verdecia MA, Joazeiro CA, Wells NJ, "et al." |title=Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. |journal=Mol. Cell |volume=11 |issue= 1 |pages= 249–59 |year= 2003 |pmid= 12535537 |doi=
*cite journal | author=Komuro A, Imamura T, Saitoh M, "et al." |title=Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). |journal=Oncogene |volume=23 |issue= 41 |pages= 6914–23 |year= 2004 |pmid= 15221015 |doi= 10.1038/sj.onc.1207885
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*cite journal | author=Seo SR, Lallemand F, Ferrand N, "et al." |title=The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. |journal=EMBO J. |volume=23 |issue= 19 |pages= 3780–92 |year= 2005 |pmid= 15359284 |doi= 10.1038/sj.emboj.7600398
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Chen C, Sun X, Guo P, "et al." |title=Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41553–61 |year= 2006 |pmid= 16223724 |doi= 10.1074/jbc.M506183200
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Flasza M, Nguyen Huu NS, Mazaleyrat S, "et al." |title=Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch. |journal=Mol. Membr. Biol. |volume=23 |issue= 3 |pages= 269–76 |year= 2006 |pmid= 16785210 |doi= 10.1080/09687860600665010
*cite journal | author=Laine A, Ronai Z |title=Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1. |journal=Oncogene |volume=26 |issue= 10 |pages= 1477–83 |year= 2007 |pmid= 16924229 |doi= 10.1038/sj.onc.1209924
*cite journal | author=Chen C, Sun X, Guo P, "et al." |title=Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. |journal=Oncogene |volume=26 |issue= 16 |pages= 2386–94 |year= 2007 |pmid= 17016436 |doi= 10.1038/sj.onc.1210021

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