PSCA (gene)

Prostate stem cell antigen, also known as PSCA, is a human gene.cite web | title = Entrez Gene: PSCA prostate stem cell antigen| url =| accessdate = ]

section_title =
summary_text = This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene has a nonsynonymous nucleotide polymorphism at its start codon.cite web | title = Entrez Gene: PSCA prostate stem cell antigen| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Reiter RE, Gu Z, Watabe T, "et al." |title=Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 4 |pages= 1735–40 |year= 1998 |pmid= 9465086 |doi=
*cite journal | author=Gu Z, Thomas G, Yamashiro J, "et al." |title=Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer. |journal=Oncogene |volume=19 |issue= 10 |pages= 1288–96 |year= 2000 |pmid= 10713670 |doi= 10.1038/sj.onc.1203426
*cite journal | author=Bahrenberg G, Brauers A, Joost HG, Jakse G |title=Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 3 |pages= 783–8 |year= 2000 |pmid= 10973799 |doi= 10.1006/bbrc.2000.3393
*cite journal | author=Amara N, Palapattu GS, Schrage M, "et al." |title=Prostate stem cell antigen is overexpressed in human transitional cell carcinoma. |journal=Cancer Res. |volume=61 |issue= 12 |pages= 4660–5 |year= 2001 |pmid= 11406532 |doi=
*cite journal | author=Watabe T, Lin M, Ide H, "et al." |title=Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 401–6 |year= 2002 |pmid= 11752398 |doi= 10.1073/pnas.012574899
*cite journal | author=Ross S, Spencer SD, Holcomb I, "et al." |title=Prostate stem cell antigen as therapy target: tissue expression and in vivo efficacy of an immunoconjugate. |journal=Cancer Res. |volume=62 |issue= 9 |pages= 2546–53 |year= 2002 |pmid= 11980648 |doi=
*cite journal | author=Jain A, Lam A, Vivanco I, "et al." |title=Identification of an androgen-dependent enhancer within the prostate stem cell antigen gene. |journal=Mol. Endocrinol. |volume=16 |issue= 10 |pages= 2323–37 |year= 2003 |pmid= 12351697 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tran CP, Lin C, Yamashiro J, Reiter RE |title=Prostate stem cell antigen is a marker of late intermediate prostate epithelial cells. |journal=Mol. Cancer Res. |volume=1 |issue= 2 |pages= 113–21 |year= 2003 |pmid= 12496358 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fraga MF, Ballestar E, Villar-Garea A, "et al." |title=Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. |journal=Nat. Genet. |volume=37 |issue= 4 |pages= 391–400 |year= 2005 |pmid= 15765097 |doi= 10.1038/ng1531
*cite journal | author=Lam JS, Yamashiro J, Shintaku IP, "et al." |title=Prostate stem cell antigen is overexpressed in prostate cancer metastases. |journal=Clin. Cancer Res. |volume=11 |issue= 7 |pages= 2591–6 |year= 2005 |pmid= 15814638 |doi= 10.1158/1078-0432.CCR-04-1842
*cite journal | author=Zhigang Z, Wenlu S |title=Complete androgen ablation suppresses prostate stem cell antigen (PSCA) mRNA expression in human prostate carcinoma. |journal=Prostate |volume=65 |issue= 4 |pages= 299–305 |year= 2006 |pmid= 16015594 |doi= 10.1002/pros.20290
*cite journal | author=Wente MN, Jain A, Kono E, "et al." |title=Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer. |journal=Pancreas |volume=31 |issue= 2 |pages= 119–25 |year= 2006 |pmid= 16024997 |doi=
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Grubbs EG, Abdel-Wahab Z, Tyler DS, Pruitt SK |title=Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer. |journal=Ann. Surg. Oncol. |volume=13 |issue= 12 |pages= 1645–54 |year= 2007 |pmid= 16957968 |doi= 10.1245/s10434-006-9029-5
*cite journal | author=Morgenroth A, Cartellieri M, Schmitz M, "et al." |title=Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells. |journal=Prostate |volume=67 |issue= 10 |pages= 1121–31 |year= 2007 |pmid= 17492652 |doi= 10.1002/pros.20608

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