GORASP1

Golgi reassembly stacking protein 1, 65kDa, also known as GORASP1, is a human gene.cite web | title = Entrez Gene: GORASP1 golgi reassembly stacking protein 1, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64689| accessdate = ]

PBB_Summary
section_title =
summary_text = The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Several alternatively spliced transcript variants of this gene have been identified, but their full-length natures have not been determined.cite web | title = Entrez Gene: GORASP1 golgi reassembly stacking protein 1, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64689| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Barr FA, Puype M, Vandekerckhove J, Warren G |title=GRASP65, a protein involved in the stacking of Golgi cisternae. |journal=Cell |volume=91 |issue= 2 |pages= 253–62 |year= 1997 |pmid= 9346242 |doi=
*cite journal | author=Barr FA, Nakamura N, Warren G |title=Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae. |journal=EMBO J. |volume=17 |issue= 12 |pages= 3258–68 |year= 1998 |pmid= 9628863 |doi= 10.1093/emboj/17.12.3258
*cite journal | author=Lin CY, Madsen ML, Yarm FR, "et al." |title=Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 23 |pages= 12589–94 |year= 2001 |pmid= 11050165 |doi= 10.1073/pnas.220423497
*cite journal | author=Moyer BD, Allan BB, Balch WE |title=Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering. |journal=Traffic |volume=2 |issue= 4 |pages= 268–76 |year= 2001 |pmid= 11285137 |doi=
*cite journal | author=Sütterlin C, Lin CY, Feng Y, "et al." |title=Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 9128–32 |year= 2001 |pmid= 11447294 |doi= 10.1073/pnas.161283998
*cite journal | author=Ward TH, Polishchuk RS, Caplan S, "et al." |title=Maintenance of Golgi structure and function depends on the integrity of ER export. |journal=J. Cell Biol. |volume=155 |issue= 4 |pages= 557–70 |year= 2001 |pmid= 11706049 |doi= 10.1083/jcb.200107045
*cite journal | author=Short B, Preisinger C, Körner R, "et al." |title=A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 877–83 |year= 2002 |pmid= 11739401 |doi= 10.1083/jcb.200108079
*cite journal | author=Barr FA, Preisinger C, Kopajtich R, Körner R |title=Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus. |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 885–91 |year= 2002 |pmid= 11739402 |doi= 10.1083/jcb.200108102
*cite journal | author=Marra P, Maffucci T, Daniele T, "et al." |title=The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment. |journal=Nat. Cell Biol. |volume=3 |issue= 12 |pages= 1101–13 |year= 2002 |pmid= 11781572 |doi= 10.1038/ncb1201-1101
*cite journal | author=Lane JD, Lucocq J, Pryde J, "et al." |title=Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis. |journal=J. Cell Biol. |volume=156 |issue= 3 |pages= 495–509 |year= 2002 |pmid= 11815631 |doi= 10.1083/jcb.200110007
*cite journal | author=Jesch SA |title=Inheriting a structural scaffold for Golgi biosynthesis. |journal=Bioessays |volume=24 |issue= 7 |pages= 584–7 |year= 2002 |pmid= 12111718 |doi= 10.1002/bies.10122
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Protopopov A, Kashuba V, Zabarovska VI, "et al." |title=An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. |journal=Cancer Res. |volume=63 |issue= 2 |pages= 404–12 |year= 2003 |pmid= 12543795 |doi=
*cite journal | author=Wang Y, Seemann J, Pypaert M, "et al." |title=A direct role for GRASP65 as a mitotically regulated Golgi stacking factor. |journal=EMBO J. |volume=22 |issue= 13 |pages= 3279–90 |year= 2003 |pmid= 12839990 |doi= 10.1093/emboj/cdg317
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wang Y, Satoh A, Warren G |title=Mapping the functional domains of the Golgi stacking factor GRASP65. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 4921–8 |year= 2005 |pmid= 15576368 |doi= 10.1074/jbc.M412407200
*cite journal | author=Yoshimura S, Yoshioka K, Barr FA, "et al." |title=Convergence of cell cycle regulation and growth factor signals on GRASP65. |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 23048–56 |year= 2005 |pmid= 15834132 |doi= 10.1074/jbc.M502442200
*cite journal | author=Sütterlin C, Polishchuk R, Pecot M, Malhotra V |title=The Golgi-associated protein GRASP65 regulates spindle dynamics and is essential for cell division. |journal=Mol. Biol. Cell |volume=16 |issue= 7 |pages= 3211–22 |year= 2005 |pmid= 15888544 |doi= 10.1091/mbc.E04-12-1065

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.