NQO2

NAD(P)H dehydrogenase, quinone 2

PDB rendering based on 1qr2.
Identifiers
Symbols NQO2; DHQV; DIA6; FLJ39868; NMOR2; QR2
External IDs OMIM160998 MGI104513 HomoloGene696 GeneCards: NQO2 Gene
EC number 1.10.99.2
RNA expression pattern
PBB GE NQO2 203814 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4835 18105
Ensembl ENSG00000124588 ENSMUSG00000046949
UniProt P16083 Q9JI75
RefSeq (mRNA) NM_000904 NM_020282
RefSeq (protein) NP_000895 NP_064678
Location (UCSC) Chr 6:
2.99 – 3.02 Mb
Chr 13:
34.06 – 34.08 Mb
PubMed search [1] [2]

NAD(P)H dehydrogenase, quinone 2, also known as NQO2 or QR2, is a human gene. It is a phase II detoxification enzyme which can carry out two or four electron reductions. Its mechanism of reduction is via a covalently bound zinc ion and a cocrystalized FAD. NQO2 contains two chains homologous in AA sequence but 7% different in structure. As a result, NQO2 contains two similar yet unique active sites. An important function of NQO2 is its activation on NRH. NQO2 can be inhibited by resveratrol.[1]


References

Further reading


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