CLC (gene)

Charcot-Leyden crystal protein, also known as CLC, is a human gene.cite web | title = Entrez Gene: CLC Charcot-Leyden crystal protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1178| accessdate = ]

PBB_Summary
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summary_text = Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.cite web | title = Entrez Gene: CLC Charcot-Leyden crystal protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1178| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gleich GJ, Loegering DA, Mann KG, Maldonado JE |title=Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils. |journal=J. Clin. Invest. |volume=57 |issue= 3 |pages= 633–40 |year= 1976 |pmid= 942977 |doi=
*cite journal | author=Golightly LM, Thomas LL, Dvorak AM, Ackerman SJ |title=Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils. |journal=J. Leukoc. Biol. |volume=51 |issue= 4 |pages= 386–92 |year= 1992 |pmid= 1373430 |doi=
*cite journal | author=Mastrianni DM, Eddy RL, Rosenberg HF, "et al." |title=Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. |journal=Genomics |volume=13 |issue= 1 |pages= 240–2 |year= 1992 |pmid= 1577491 |doi=
*cite journal | author=Dvorak AM, Weller PF, Monahan-Earley RA, "et al." |title=Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome. |journal=Lab. Invest. |volume=62 |issue= 5 |pages= 590–607 |year= 1990 |pmid= 2160562 |doi=
*cite journal | author=Dvorak AM, Letourneau L, Weller PF, Ackerman SJ |title=Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas. |journal=Lab. Invest. |volume=62 |issue= 5 |pages= 608–15 |year= 1990 |pmid= 2160563 |doi=
*cite journal | author=Dvorak AM, Ackerman SJ |title=Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to granules and intragranular crystals in mature human basophils. |journal=Lab. Invest. |volume=60 |issue= 4 |pages= 557–67 |year= 1989 |pmid= 2709814 |doi=
*cite journal | author=Sieker LC, Turley S, Le Trong I, "et al." |title=Crystallographic characterization of human eosinophil Charcot-Leyden crystals. |journal=J. Mol. Biol. |volume=204 |issue= 2 |pages= 489–91 |year= 1989 |pmid= 3221396 |doi=
*cite journal | author=Weller PF, Bach D, Austen KF |title=Human eosinophil lysophospholipase: the sole protein component of Charcot-Leyden crystals. |journal=J. Immunol. |volume=128 |issue= 3 |pages= 1346–9 |year= 1982 |pmid= 6173432 |doi=
*cite journal | author=Weller PF, Bach DS, Austen KF |title=Biochemical characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). |journal=J. Biol. Chem. |volume=259 |issue= 24 |pages= 15100–5 |year= 1985 |pmid= 6511787 |doi=
*cite journal | author=Gomolin HI, Yamaguchi Y, Paulpillai AV, "et al." |title=Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter. |journal=Blood |volume=82 |issue= 6 |pages= 1868–74 |year= 1993 |pmid= 8400237 |doi=
*cite journal | author=Ackerman SJ, Corrette SE, Rosenberg HF, "et al." |title=Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily. |journal=J. Immunol. |volume=150 |issue= 2 |pages= 456–68 |year= 1993 |pmid= 8419478 |doi=
*cite journal | author=Leonidas DD, Elbert BL, Zhou Z, "et al." |title=Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins. |journal=Structure |volume=3 |issue= 12 |pages= 1379–93 |year= 1996 |pmid= 8747464 |doi=
*cite journal | author=Dyer KD, Handen JS, Rosenberg HF |title=The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes. |journal=Genomics |volume=40 |issue= 2 |pages= 217–21 |year= 1997 |pmid= 9119387 |doi= 10.1006/geno.1996.4590
*cite journal | author=Swaminathan GJ, Leonidas DD, Savage MP, "et al." |title=Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution. |journal=Biochemistry |volume=38 |issue= 42 |pages= 13837–43 |year= 1999 |pmid= 10529229 |doi=
*cite journal | author=Larramendy ML, Niini T, Elonen E, "et al." |title=Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis. |journal=Haematologica |volume=87 |issue= 6 |pages= 569–77 |year= 2003 |pmid= 12031912 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Abedin MJ, Kashio Y, Seki M, "et al." |title=Potential roles of galectins in myeloid differentiation into three different lineages. |journal=J. Leukoc. Biol. |volume=73 |issue= 5 |pages= 650–6 |year= 2003 |pmid= 12714580 |doi=
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Nielsen K, Heegaard S, Vorum H, "et al." |title=Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients. |journal=Cornea |volume=24 |issue= 6 |pages= 661–8 |year= 2005 |pmid= 16015083 |doi=

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