Replication factor C (activator 1) 5, 36.5kDa, also known as RFC5, is a human gene.cite web | title = Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5985| accessdate = ]

section_title =
summary_text = The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5985| accessdate = ]


Further reading

citations =
*cite journal | author=Okumura K, Nogami M, Taguchi H, "et al." |title=Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. |journal=Genomics |volume=25 |issue= 1 |pages= 274–8 |year= 1995 |pmid= 7774928 |doi=
*cite journal | author=O'Donnell M, Onrust R, Dean FB, "et al." |title=Homology in accessory proteins of replicative polymerases--E. coli to humans. |journal=Nucleic Acids Res. |volume=21 |issue= 1 |pages= 1–3 |year= 1993 |pmid= 8441605 |doi=
*cite journal | author=Uhlmann F, Cai J, Flores-Rozas H, "et al." |title=In vitro reconstitution of human replication factor C from its five subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6521–6 |year= 1996 |pmid= 8692848 |doi=
*cite journal | author=Mossi R, Jónsson ZO, Allen BL, "et al." |title=Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1769–76 |year= 1997 |pmid= 8999859 |doi=
*cite journal | author=Cujec TP, Cho H, Maldonado E, "et al." |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817–23 |year= 1997 |pmid= 9121429 |doi=
*cite journal | author=Cai J, Gibbs E, Uhlmann F, "et al." |title=A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 18974–81 |year= 1997 |pmid= 9228079 |doi=
*cite journal | author=Loor G, Zhang SJ, Zhang P, "et al." |title=Identification of DNA replication and cell cycle proteins that interact with PCNA. |journal=Nucleic Acids Res. |volume=25 |issue= 24 |pages= 5041–6 |year= 1998 |pmid= 9396813 |doi=
*cite journal | author=Ellison V, Stillman B |title=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5979–87 |year= 1998 |pmid= 9488738 |doi=
*cite journal | author=Cai J, Yao N, Gibbs E, "et al." |title=ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 20 |pages= 11607–12 |year= 1998 |pmid= 9751713 |doi=
*cite journal | author=Zhang G, Gibbs E, Kelman Z, "et al." |title=Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1869–74 |year= 1999 |pmid= 10051561 |doi=
*cite journal | author=Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A |title=Purification and characterization of human DNA damage checkpoint Rad complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 20 |pages= 11236–41 |year= 2001 |pmid= 11572977 |doi= 10.1073/pnas.201373498
*cite journal | author=Griffith JD, Lindsey-Boltz LA, Sancar A |title=Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15233–6 |year= 2002 |pmid= 11907025 |doi= 10.1074/jbc.C200129200
*cite journal | author=Ohta S, Shiomi Y, Sugimoto K, "et al." |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362–7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200
*cite journal | author=Maruyama T, Farina A, Dey A, "et al." |title=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6509–20 |year= 2002 |pmid= 12192049 |doi=
*cite journal | author=Venclovas C, Colvin ME, Thelen MP |title=Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process. |journal=Protein Sci. |volume=11 |issue= 10 |pages= 2403–16 |year= 2003 |pmid= 12237462 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J |title=Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30051–6 |year= 2003 |pmid= 12766176 |doi= 10.1074/jbc.M211591200
*cite journal | author=Bermudez VP, Maniwa Y, Tappin I, "et al." |title=The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 18 |pages= 10237–42 |year= 2003 |pmid= 12930902 |doi= 10.1073/pnas.1434308100
*cite journal | author=Zou L, Liu D, Elledge SJ |title=Replication protein A-mediated recruitment and activation of Rad17 complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 13827–32 |year= 2004 |pmid= 14605214 |doi= 10.1073/pnas.2336100100
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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