Solute carrier family 26, member 3, also known as SLC26A3, or DRA is a human gene.cite web | title = Entrez Gene: SLC26A3 solute carrier family 26, member 3| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a transmembrane glycoprotein that functions as a sulfate transporter. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. Mutations in this gene have been associated with congenital chloride diarrhea.cite web | title = Entrez Gene: SLC26A3 solute carrier family 26, member 3| url =| accessdate = ]

ee also

* Solute carrier family


Further reading

citations =
*cite journal | author=Sandal NN, Marcker KA |title=Similarities between a soybean nodulin, Neurospora crassa sulphate permease II and a putative human tumour suppressor. |journal=Trends Biochem. Sci. |volume=19 |issue= 1 |pages= 19 |year= 1994 |pmid= 8140616 |doi=
*cite journal | author=Markovich D |title=Physiological roles and regulation of mammalian sulfate transporters. |journal=Physiol. Rev. |volume=81 |issue= 4 |pages= 1499–533 |year= 2001 |pmid= 11581495 |doi=
*cite journal | author=Mäkelä S, Kere J, Holmberg C, Höglund P |title=SLC26A3 mutations in congenital chloride diarrhea. |journal=Hum. Mutat. |volume=20 |issue= 6 |pages= 425–38 |year= 2002 |pmid= 12442266 |doi= 10.1002/humu.10139
*cite journal | author=Schweinfest CW, Henderson KW, Suster S, "et al." |title=Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 9 |pages= 4166–70 |year= 1993 |pmid= 7683425 |doi=
*cite journal | author=Taguchi T, Testa JR, Papas TS, Schweinfest C |title=Localization of a candidate colon tumor-suppressor gene (DRA) to 7q22-q31.1 by fluorescence in situ hybridization. |journal=Genomics |volume=20 |issue= 1 |pages= 146–7 |year= 1994 |pmid= 8020951 |doi= 10.1006/geno.1994.1148
*cite journal | author=Höglund P, Haila S, Socha J, "et al." |title=Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. |journal=Nat. Genet. |volume=14 |issue= 3 |pages= 316–9 |year= 1996 |pmid= 8896562 |doi= 10.1038/ng1196-316
*cite journal | author=Byeon MK, Frankel A, Papas TS, "et al." |title=Human DRA functions as a sulfate transporter in Sf9 insect cells. |journal=Protein Expr. Purif. |volume=12 |issue= 1 |pages= 67–74 |year= 1998 |pmid= 9473459 |doi= 10.1006/prep.1997.0809
*cite journal | author=Höglund P, Haila S, Gustavson KH, "et al." |title=Clustering of private mutations in the congenital chloride diarrhea/down-regulated in adenoma gene. |journal=Hum. Mutat. |volume=11 |issue= 4 |pages= 321–7 |year= 1998 |pmid= 9554749 |doi= 10.1002/(SICI)1098-1004(1998)11:4<321::AID-HUMU10>3.0.CO;2-A |doilabel=10.1002/(SICI)1098-1004(1998)11:4321::AID-HUMU103.0.CO;2-A
*cite journal | author=Antalis TM, Reeder JA, Gotley DC, "et al." |title=Down-regulation of the down-regulated in adenoma (DRA) gene correlates with colon tumor progression. |journal=Clin. Cancer Res. |volume=4 |issue= 8 |pages= 1857–63 |year= 1998 |pmid= 9717812 |doi=
*cite journal | author=Höglund P, Auranen M, Socha J, "et al." |title=Genetic background of congenital chloride diarrhea in high-incidence populations: Finland, Poland, and Saudi Arabia and Kuwait. |journal=Am. J. Hum. Genet. |volume=63 |issue= 3 |pages= 760–8 |year= 1998 |pmid= 9718329 |doi=
*cite journal | author=Lohi H, Kujala M, Kerkelä E, "et al." |title=Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. |journal=Genomics |volume=70 |issue= 1 |pages= 102–12 |year= 2001 |pmid= 11087667 |doi= 10.1006/geno.2000.6355
*cite journal | author=Höglund P, Sormaala M, Haila S, "et al." |title=Identification of seven novel mutations including the first two genomic rearrangements in SLC26A3 mutated in congenital chloride diarrhea. |journal=Hum. Mutat. |volume=18 |issue= 3 |pages= 233–42 |year= 2001 |pmid= 11524734 |doi= 10.1002/humu.1179
*cite journal | author=Lohi H, Kujala M, Makela S, "et al." |title=Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 14246–54 |year= 2002 |pmid= 11834742 |doi= 10.1074/jbc.M111802200
*cite journal | author=Lamprecht G, Heil A, Baisch S, "et al." |title=The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange. |journal=Biochemistry |volume=41 |issue= 41 |pages= 12336–42 |year= 2002 |pmid= 12369822 |doi=
*cite journal | author=Sterling D, Brown NJ, Supuran CT, Casey JR |title=The functional and physical relationship between the DRA bicarbonate transporter and carbonic anhydrase II. |journal=Am. J. Physiol., Cell Physiol. |volume=283 |issue= 5 |pages= C1522–9 |year= 2002 |pmid= 12372813 |doi= 10.1152/ajpcell.00115.2002
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chernova MN, Jiang L, Shmukler BE, "et al." |title=Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. |journal=J. Physiol. (Lond.) |volume=549 |issue= Pt 1 |pages= 3–19 |year= 2004 |pmid= 12651923 |doi= 10.1113/jphysiol.2003.039818

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