PIK3C2B


PIK3C2B

Phosphoinositide-3-kinase, class 2, beta polypeptide, also known as PIK3C2B, is a human gene.cite web | title = Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.cite web | title = Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lee C, Liu QH, Tomkowicz B, "et al." |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206
*cite journal | author=Kozutsumi H, Toyoshima H, Hagiwara K, "et al." |title=Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. |journal=Oncogene |volume=9 |issue= 10 |pages= 2991–8 |year= 1994 |pmid= 8084603 |doi=
*cite journal | author=Milani D, Mazzoni M, Borgatti P, "et al." |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961–4 |year= 1996 |pmid= 8798481 |doi=
*cite journal | author=Brown RA, Ho LK, Weber-Hall SJ, "et al." |title=Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 2 |pages= 537–44 |year= 1997 |pmid= 9144573 |doi= 10.1006/bbrc.1997.6495
*cite journal | author=Ueno H, Honda H, Nakamoto T, "et al." |title=The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase. |journal=Oncogene |volume=14 |issue= 25 |pages= 3067–72 |year= 1997 |pmid= 9223670 |doi= 10.1038/sj.onc.1201153
*cite journal | author=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457–65 |year= 1997 |pmid= 9341793 |doi=
*cite journal | author=Borgatti P, Zauli G, Colamussi ML, "et al." |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805–11 |year= 1998 |pmid= 9394803 |doi=
*cite journal | author=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–7 |year= 1998 |pmid= 9446795 |doi=
*cite journal | author=Milani D, Mazzoni M, Zauli G, "et al." |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275–84 |year= 1998 |pmid= 9708406 |doi=
*cite journal | author=Jauliac S, Mazerolles F, Jabado N, "et al." |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183–91 |year= 1998 |pmid= 9808187 |doi=
*cite journal | author=Arcaro A, Volinia S, Zvelebil MJ, "et al." |title=Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 33082–90 |year= 1999 |pmid= 9830063 |doi=
*cite journal | author=Arcaro A, Zvelebil MJ, Wallasch C, "et al." |title=Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3817–30 |year= 2000 |pmid= 10805725 |doi=
*cite journal | author=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352–8 |year= 2001 |pmid= 11154208 |doi=
*cite journal | author=Zauli G, Milani D, Mirandola P, "et al." |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com
*cite journal | author=Wheeler M, Domin J |title=Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. |journal=Mol. Cell. Biol. |volume=21 |issue= 19 |pages= 6660–7 |year= 2001 |pmid= 11533253 |doi=
*cite journal | author=Deregibus MC, Cantaluppi V, Doublier S, "et al." |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195–202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200
*cite journal | author=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254–60 |year= 2002 |pmid= 12077252 |doi=
*cite journal | author=Arcaro A, Khanzada UK, Vanhaesebroeck B, "et al." |title=Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5097–108 |year= 2002 |pmid= 12356726 |doi=
*cite journal | author=Visnjić D, Crljen V, Curić J, "et al." |title=The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 268–74 |year= 2002 |pmid= 12372612 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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