CAMK2D

Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta, also known as CAMK2D, is a human gene.cite web | title = Entrez Gene: CAMK2D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=817| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.cite web | title = Entrez Gene: CAMK2D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=817| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hook SS, Means AR |title=Ca(2+)/CaM-dependent kinases: from activation to function. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=41 |issue= |pages= 471–505 |year= 2001 |pmid= 11264466 |doi= 10.1146/annurev.pharmtox.41.1.471
*cite journal | author=Yamamoto H |title= [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 3 |pages= 241–7 |year= 2002 |pmid= 11889801 |doi=
*cite journal | author=de Groot RP, den Hertog J, Vandenheede JR, "et al." |title=Multiple and cooperative phosphorylation events regulate the CREM activator function. |journal=EMBO J. |volume=12 |issue= 10 |pages= 3903–11 |year= 1993 |pmid= 8404858 |doi=
*cite journal | author=Tombes RM, Krystal GW |title=Identification of novel human tumor cell-specific CaMK-II variants. |journal=Biochim. Biophys. Acta |volume=1355 |issue= 3 |pages= 281–92 |year= 1997 |pmid= 9060999 |doi=
*cite journal | author=Moyers JS, Bilan PJ, Zhu J, Kahn CR |title=Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11832–9 |year= 1997 |pmid= 9115241 |doi=
*cite journal | author=Möhlig M, Wolter S, Mayer P, "et al." |title=Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles. |journal=Endocrinology |volume=138 |issue= 6 |pages= 2577–84 |year= 1997 |pmid= 9165051 |doi=
*cite journal | author=Bauch A, Campbell KS, Reth M |title=Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta. |journal=Eur. J. Immunol. |volume=28 |issue= 7 |pages= 2167–77 |year= 1998 |pmid= 9692886 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Hoch B, Meyer R, Hetzer R, "et al." |title=Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. |journal=Circ. Res. |volume=84 |issue= 6 |pages= 713–21 |year= 1999 |pmid= 10189359 |doi=
*cite journal | author=Tombes RM, Mikkelsen RB, Jarvis WD, Grant S |title=Downregulation of delta CaM kinase II in human tumor cells. |journal=Biochim. Biophys. Acta |volume=1452 |issue= 1 |pages= 1–11 |year= 1999 |pmid= 10525155 |doi=
*cite journal | author=Rochlitz H, Voigt A, Lankat-Buttgereit B, "et al." |title=Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells. |journal=Diabetologia |volume=43 |issue= 4 |pages= 465–73 |year= 2000 |pmid= 10819240 |doi=
*cite journal | author=Inagaki N, Nishizawa M, Arimura N, "et al." |title=Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27165–71 |year= 2000 |pmid= 10852918 |doi= 10.1074/jbc.M003751200
*cite journal | author=Nair JS, DaFonseca CJ, Tjernberg A, "et al." |title=Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 9 |pages= 5971–6 |year= 2002 |pmid= 11972023 |doi= 10.1073/pnas.052159099
*cite journal | author=Mishra-Gorur K, Singer HA, Castellot JJ |title=The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 33537–40 |year= 2002 |pmid= 12145273 |doi= 10.1074/jbc.C200342200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gaertner TR, Kolodziej SJ, Wang D, "et al." |title=Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12484–94 |year= 2004 |pmid= 14722083 |doi= 10.1074/jbc.M313597200
*cite journal | author=Ballif BA, Villén J, Beausoleil SA, "et al." |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200

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