RFC2

Replication factor C (activator 1) 2, 40kDa, also known as RFC2, is a human gene.cite web | title = Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5982| accessdate = ]

PBB_Summary
section_title =
summary_text = The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.cite web | title = Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5982| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chen M, Pan ZQ, Hurwitz J |title=Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 7 |pages= 2516–20 |year= 1992 |pmid= 1313560 |doi=
*cite journal | author=Okumura K, Nogami M, Taguchi H, "et al." |title=Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. |journal=Genomics |volume=25 |issue= 1 |pages= 274–8 |year= 1995 |pmid= 7774928 |doi=
*cite journal | author=Pan ZQ, Chen M, Hurwitz J |title=The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 1 |pages= 6–10 |year= 1993 |pmid= 8093561 |doi=
*cite journal | author=Peoples R, Perez-Jurado L, Wang YK, "et al." |title=The gene for replication factor C subunit 2 (RFC2) is within the 7q11.23 Williams syndrome deletion. |journal=Am. J. Hum. Genet. |volume=58 |issue= 6 |pages= 1370–3 |year= 1996 |pmid= 8651315 |doi=
*cite journal | author=Uhlmann F, Cai J, Flores-Rozas H, "et al." |title=In vitro reconstitution of human replication factor C from its five subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6521–6 |year= 1996 |pmid= 8692848 |doi=
*cite journal | author=Osborne LR, Martindale D, Scherer SW, "et al." |title=Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. |journal=Genomics |volume=36 |issue= 2 |pages= 328–36 |year= 1997 |pmid= 8812460 |doi= 10.1006/geno.1996.0469
*cite journal | author=Cujec TP, Cho H, Maldonado E, "et al." |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817–23 |year= 1997 |pmid= 9121429 |doi=
*cite journal | author=Cai J, Gibbs E, Uhlmann F, "et al." |title=A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 18974–81 |year= 1997 |pmid= 9228079 |doi=
*cite journal | author=Ellison V, Stillman B |title=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5979–87 |year= 1998 |pmid= 9488738 |doi=
*cite journal | author=Zhang G, Gibbs E, Kelman Z, "et al." |title=Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1869–74 |year= 1999 |pmid= 10051561 |doi=
*cite journal | author=Wang Y, Cortez D, Yazdi P, "et al." |title=BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. |journal=Genes Dev. |volume=14 |issue= 8 |pages= 927–39 |year= 2000 |pmid= 10783165 |doi=
*cite journal | author=Martindale DW, Wilson MD, Wang D, "et al." |title=Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 890–8 |year= 2000 |pmid= 11003705 |doi=
*cite journal | author=Griffith JD, Lindsey-Boltz LA, Sancar A |title=Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15233–6 |year= 2002 |pmid= 11907025 |doi= 10.1074/jbc.C200129200
*cite journal | author=Nieborowska-Skorska M, Hoser G, Kossev P, "et al." |title=Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis. |journal=Blood |volume=99 |issue= 12 |pages= 4531–9 |year= 2002 |pmid= 12036885 |doi=
*cite journal | author=Ohta S, Shiomi Y, Sugimoto K, "et al." |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362–7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200
*cite journal | author=Maruyama T, Farina A, Dey A, "et al." |title=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6509–20 |year= 2002 |pmid= 12192049 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J |title=Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30051–6 |year= 2003 |pmid= 12766176 |doi= 10.1074/jbc.M211591200
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Bermudez VP, Maniwa Y, Tappin I, "et al." |title=The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 18 |pages= 10237–42 |year= 2003 |pmid= 12930902 |doi= 10.1073/pnas.1434308100

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