Replication factor C (activator 1) 2, 40kDa, also known as RFC2, is a human gene.cite web | title = Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5982| accessdate = ]

section_title =
summary_text = The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.cite web | title = Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5982| accessdate = ]


Further reading

citations =
*cite journal | author=Chen M, Pan ZQ, Hurwitz J |title=Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 7 |pages= 2516–20 |year= 1992 |pmid= 1313560 |doi=
*cite journal | author=Okumura K, Nogami M, Taguchi H, "et al." |title=Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. |journal=Genomics |volume=25 |issue= 1 |pages= 274–8 |year= 1995 |pmid= 7774928 |doi=
*cite journal | author=Pan ZQ, Chen M, Hurwitz J |title=The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 1 |pages= 6–10 |year= 1993 |pmid= 8093561 |doi=
*cite journal | author=Peoples R, Perez-Jurado L, Wang YK, "et al." |title=The gene for replication factor C subunit 2 (RFC2) is within the 7q11.23 Williams syndrome deletion. |journal=Am. J. Hum. Genet. |volume=58 |issue= 6 |pages= 1370–3 |year= 1996 |pmid= 8651315 |doi=
*cite journal | author=Uhlmann F, Cai J, Flores-Rozas H, "et al." |title=In vitro reconstitution of human replication factor C from its five subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6521–6 |year= 1996 |pmid= 8692848 |doi=
*cite journal | author=Osborne LR, Martindale D, Scherer SW, "et al." |title=Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. |journal=Genomics |volume=36 |issue= 2 |pages= 328–36 |year= 1997 |pmid= 8812460 |doi= 10.1006/geno.1996.0469
*cite journal | author=Cujec TP, Cho H, Maldonado E, "et al." |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817–23 |year= 1997 |pmid= 9121429 |doi=
*cite journal | author=Cai J, Gibbs E, Uhlmann F, "et al." |title=A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 18974–81 |year= 1997 |pmid= 9228079 |doi=
*cite journal | author=Ellison V, Stillman B |title=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5979–87 |year= 1998 |pmid= 9488738 |doi=
*cite journal | author=Zhang G, Gibbs E, Kelman Z, "et al." |title=Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1869–74 |year= 1999 |pmid= 10051561 |doi=
*cite journal | author=Wang Y, Cortez D, Yazdi P, "et al." |title=BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. |journal=Genes Dev. |volume=14 |issue= 8 |pages= 927–39 |year= 2000 |pmid= 10783165 |doi=
*cite journal | author=Martindale DW, Wilson MD, Wang D, "et al." |title=Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 890–8 |year= 2000 |pmid= 11003705 |doi=
*cite journal | author=Griffith JD, Lindsey-Boltz LA, Sancar A |title=Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15233–6 |year= 2002 |pmid= 11907025 |doi= 10.1074/jbc.C200129200
*cite journal | author=Nieborowska-Skorska M, Hoser G, Kossev P, "et al." |title=Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis. |journal=Blood |volume=99 |issue= 12 |pages= 4531–9 |year= 2002 |pmid= 12036885 |doi=
*cite journal | author=Ohta S, Shiomi Y, Sugimoto K, "et al." |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362–7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200
*cite journal | author=Maruyama T, Farina A, Dey A, "et al." |title=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6509–20 |year= 2002 |pmid= 12192049 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J |title=Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30051–6 |year= 2003 |pmid= 12766176 |doi= 10.1074/jbc.M211591200
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Bermudez VP, Maniwa Y, Tappin I, "et al." |title=The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 18 |pages= 10237–42 |year= 2003 |pmid= 12930902 |doi= 10.1073/pnas.1434308100

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Socks — сетевой протокол, который позволяет клиент серверным приложениям прозрачно использовать сервисы за межсетевыми экранами (фаерволами). SOCKS это сокращение от «SOCKetS» (сокеты, гнёзда). Клиенты за межсетевым экраном, нуждающиеся в доступе к… …   Википедия

  • Williams syndrome — Infobox Disease Name = Williams syndrome Caption = DiseasesDB = ICD10 = ICD10|Q|93|8|q|90 ICD9 = ICD9|758.9 ICDO = OMIM = 194050 MedlinePlus = 001116 eMedicineSubj = ped eMedicineTopic = 2439 MeshID = D018980 Williams syndrome (WS; also Williams… …   Wikipedia

  • AAA proteins — Pfam box Symbol = AAA Name = ATPases associated with diverse cellular activities (AAA) width = caption = Pfam= PF00004 InterPro= IPR003959 SMART= PROSITE= PDOC00572 SCOP = 1nsf TCDB = OPM family= OPM protein= PDB=PDB3|1jbkA:201 286 PDB3|1qvrC:193 …   Wikipedia

  • Replication factor C — The replication factor C, or RFC, is a five subunit protein complex that is required for DNA replication.The subunits of this heteropentamer are named Rfc1, Rfc2, Rfc3, Rfc4, and Rfc5 (in S. cerevisiae). RFC is used in eukaryotic replication as a …   Wikipedia

  • LIMK1 — LIM domain kinase 1, also known as LIMK1, is a human gene. PBB Summary section title = summary text = There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine… …   Wikipedia

  • RFC4 — Replication factor C (activator 1) 4, 37kDa, also known as RFC4, is a human gene.cite web | title = Entrez Gene: RFC4 replication factor C (activator 1) 4, 37kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • RFC3 — Replication factor C (activator 1) 3, 38kDa, also known as RFC3, is a human gene.cite web | title = Entrez Gene: RFC3 replication factor C (activator 1) 3, 38kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • RFC5 — Replication factor C (activator 1) 5, 36.5kDa, also known as RFC5, is a human gene.cite web | title = Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • LAT2 — Linker for activation of T cells family, member 2, also known as LAT2, is a human gene.cite web | title = Entrez Gene: LAT2 linker for activation of T cells family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • EIF4H — Eukaryotic translation initiation factor 4H, also known as EIF4H, is a human gene.cite web | title = Entrez Gene: EIF4H eukaryotic translation initiation factor 4H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.