High-mobility group box 2, also known as HMGB2, is a human gene.cite web | title = Entrez Gene: HMGB2 high-mobility group box 2| url =| accessdate = ]

section_title =
summary_text = This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.cite web | title = Entrez Gene: HMGB2 high-mobility group box 2| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Alexandre S, Li WW, Lee AS |title=A human HMG2 cDNA with a novel 3'-untranslated region. |journal=Nucleic Acids Res. |volume=20 |issue= 23 |pages= 6413 |year= 1993 |pmid= 1475204 |doi=
*cite journal | author=Shirakawa H, Yoshida M |title=Structure of a gene coding for human HMG2 protein. |journal=J. Biol. Chem. |volume=267 |issue= 10 |pages= 6641–5 |year= 1992 |pmid= 1551873 |doi=
*cite journal | author=Majumdar A, Brown D, Kerby S, "et al." |title=Sequence of human HMG2 cDNA. |journal=Nucleic Acids Res. |volume=19 |issue= 23 |pages= 6643 |year= 1992 |pmid= 1754403 |doi=
*cite journal | author=Bernués J, Espel E, Querol E |title=Identification of the core-histone-binding domains of HMG1 and HMG2. |journal=Biochim. Biophys. Acta |volume=866 |issue= 4 |pages= 242–51 |year= 1986 |pmid= 3697355 |doi=
*cite journal | author=Zwilling S, König H, Wirth T |title=High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. |journal=EMBO J. |volume=14 |issue= 6 |pages= 1198–208 |year= 1995 |pmid= 7720710 |doi=
*cite journal | author=Shykind BM, Kim J, Sharp PA |title=Activation of the TFIID-TFIIA complex with HMG-2. |journal=Genes Dev. |volume=9 |issue= 11 |pages= 1354–65 |year= 1995 |pmid= 7797075 |doi=
*cite journal | author=Paull TT, Haykinson MJ, Johnson RC |title=The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures. |journal=Genes Dev. |volume=7 |issue= 8 |pages= 1521–34 |year= 1993 |pmid= 8339930 |doi=
*cite journal | author=Wanschura S, Schoenmakers EF, Huysmans C, "et al." |title=Mapping of the human HMG2 gene to 4q31. |journal=Genomics |volume=31 |issue= 2 |pages= 264–5 |year= 1997 |pmid= 8824816 |doi=
*cite journal | author=Nagaki S, Yamamoto M, Yumoto Y, "et al." |title=Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks. |journal=Biochem. Biophys. Res. Commun. |volume=246 |issue= 1 |pages= 137–41 |year= 1998 |pmid= 9600082 |doi= 10.1006/bbrc.1998.8589
*cite journal | author=Boonyaratanakornkit V, Melvin V, Prendergast P, "et al." |title=High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells. |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4471–87 |year= 1998 |pmid= 9671457 |doi=
*cite journal | author=Yumoto Y, Shirakawa H, Yoshida M, "et al." |title=High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro. |journal=J. Biochem. |volume=124 |issue= 3 |pages= 519–27 |year= 1998 |pmid= 9722660 |doi=
*cite journal | author=Aidinis V, Bonaldi T, Beltrame M, "et al." |title=The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6532–42 |year= 2000 |pmid= 10490593 |doi=
*cite journal | author=Butteroni C, De Felici M, Schöler HR, Pesce M |title=Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins. |journal=J. Mol. Biol. |volume=304 |issue= 4 |pages= 529–40 |year= 2001 |pmid= 11099378 |doi= 10.1006/jmbi.2000.4238
*cite journal | author=Stros M, Ozaki T, Bacikova A, "et al." |title=HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7157–64 |year= 2002 |pmid= 11748232 |doi= 10.1074/jbc.M110233200
*cite journal | author=Fan Z, Beresford PJ, Zhang D, Lieberman J |title=HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2810–20 |year= 2002 |pmid= 11909973 |doi=
*cite journal | author=Dubois T, Howell S, Zemlickova E, Aitken A |title=Identification of casein kinase Ialpha interacting protein partners. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 167–71 |year= 2002 |pmid= 12062430 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fan Z, Beresford PJ, Zhang D, "et al." |title=Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. |journal=Nat. Immunol. |volume=4 |issue= 2 |pages= 145–53 |year= 2003 |pmid= 12524539 |doi= 10.1038/ni885
*cite journal | author=Lv X, Xu DD, Liu DP, "et al." |title=High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster. |journal=Biochem. Cell Biol. |volume=80 |issue= 6 |pages= 765–70 |year= 2003 |pmid= 12555809 |doi=
*cite journal | author=Pallier C, Scaffidi P, Chopineau-Proust S, "et al." |title=Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes. |journal=Mol. Biol. Cell |volume=14 |issue= 8 |pages= 3414–26 |year= 2004 |pmid= 12925773 |doi= 10.1091/mbc.E02-09-0581

External links


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  • High mobility group — or HMG is a group of chromosomal proteins that help with transcription, replication, recombination, and DNA repair.cite journal | author = Rajeswari MR, Jain A | title = High mobility group chromosomal proteins, HMGA1 as potential tumour markers… …   Wikipedia

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