Calcium/calmodulin-dependent protein kinase I, also known as CAMK1, is a human gene.cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url =| accessdate = ]

section_title =
summary_text = Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Bredt DS, Ferris CD, Snyder SH |title=Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10976–81 |year= 1992 |pmid= 1375933 |doi=
*cite journal | author=Yokokura H, Picciotto MR, Nairn AC, Hidaka H |title=The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains. |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23851–9 |year= 1995 |pmid= 7559563 |doi=
*cite journal | author=Haribabu B, Hook SS, Selbert MA, "et al." |title=Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. |journal=EMBO J. |volume=14 |issue= 15 |pages= 3679–86 |year= 1995 |pmid= 7641687 |doi=
*cite journal | author=Liu F, Thompson MA, Wagner S, "et al." |title=Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation. |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6714–20 |year= 1993 |pmid= 8384217 |doi=
*cite journal | author=Chin D, Winkler KE, Means AR |title=Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31235–40 |year= 1998 |pmid= 9395448 |doi=
*cite journal | author=Hsu LS, Tsou AP, Chi CW, "et al." |title=Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. |journal=J. Biomed. Sci. |volume=5 |issue= 2 |pages= 141–9 |year= 1998 |pmid= 9662074 |doi=
*cite journal | author=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473–81 |year= 1998 |pmid= 9705275 |doi=
*cite journal | author=Anderson KA, Means RL, Huang QH, "et al." |title=Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31880–9 |year= 1998 |pmid= 9822657 |doi=
*cite journal | author=Matsushita M, Nairn AC |title=Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10086–93 |year= 1999 |pmid= 10187789 |doi=
*cite journal | author=Hayashi Y, Nishio M, Naito Y, "et al." |title=Regulation of neuronal nitric-oxide synthase by calmodulin kinases. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20597–602 |year= 1999 |pmid= 10400690 |doi=
*cite journal | author=Hosaka M, Hammer RE, Südhof TC |title=A phospho-switch controls the dynamic association of synapsins with synaptic vesicles. |journal=Neuron |volume=24 |issue= 2 |pages= 377–87 |year= 1999 |pmid= 10571231 |doi=
*cite journal | author=Komeima K, Hayashi Y, Naito Y, Watanabe Y |title=Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28139–43 |year= 2000 |pmid= 10874031 |doi= 10.1074/jbc.M003198200
*cite journal | author=McKinsey TA, Zhang CL, Lu J, Olson EN |title=Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. |journal=Nature |volume=408 |issue= 6808 |pages= 106–11 |year= 2000 |pmid= 11081517 |doi= 10.1038/35040593
*cite journal | author=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400–5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497
*cite journal | author=Hsu LS, Chen GD, Lee LS, "et al." |title=Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31113–23 |year= 2001 |pmid= 11395482 |doi= 10.1074/jbc.M011720200
*cite journal | author=Condon JC, Pezzi V, Drummond BM, "et al." |title=Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. |journal=Endocrinology |volume=143 |issue= 9 |pages= 3651–7 |year= 2002 |pmid= 12193581 |doi=
*cite journal | author=Sakurada K, Kato H, Nagumo H, "et al." |title=Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45473–9 |year= 2003 |pmid= 12237306 |doi= 10.1074/jbc.M206673200
*cite journal | author=Clapperton JA, Martin SR, Smerdon SJ, "et al." |title=Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism. |journal=Biochemistry |volume=41 |issue= 50 |pages= 14669–79 |year= 2003 |pmid= 12475216 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Izmailova E, Bertley FM, Huang Q, "et al." |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822

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