FKBP5


FKBP5

FK506 binding protein 5, also known as FKBP5, is a human gene.cite web | title = Entrez Gene: FKBP5 FK506 binding protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2289| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites.cite web | title = Entrez Gene: FKBP5 FK506 binding protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2289| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schiene-Fischer C, Yu C |title=Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. |journal=FEBS Lett. |volume=495 |issue= 1-2 |pages= 1–6 |year= 2001 |pmid= 11322937 |doi=
*cite journal | author=Baughman G, Wiederrecht GJ, Campbell NF, "et al." |title=FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition. |journal=Mol. Cell. Biol. |volume=15 |issue= 8 |pages= 4395–402 |year= 1995 |pmid= 7542743 |doi=
*cite journal | author=Smith DF, Baggenstoss BA, Marion TN, Rimerman RA |title=Two FKBP-related proteins are associated with progesterone receptor complexes. |journal=J. Biol. Chem. |volume=268 |issue= 24 |pages= 18365–71 |year= 1993 |pmid= 7688746 |doi=
*cite journal | author=Smith DF, Albers MW, Schreiber SL, "et al." |title=FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 24270–3 |year= 1993 |pmid= 7693698 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Johnson J, Corbisier R, Stensgard B, Toft D |title=The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=56 |issue= 1-6 Spec No |pages= 31–7 |year= 1996 |pmid= 8603045 |doi=
*cite journal | author=Nair SC, Rimerman RA, Toran EJ, "et al." |title=Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. |journal=Mol. Cell. Biol. |volume=17 |issue= 2 |pages= 594–603 |year= 1997 |pmid= 9001212 |doi=
*cite journal | author=Baughman G, Wiederrecht GJ, Chang F, "et al." |title=Tissue distribution and abundance of human FKBP51, and FK506-binding protein that can mediate calcineurin inhibition. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 2 |pages= 437–43 |year= 1997 |pmid= 9125197 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Young JC, Obermann WM, Hartl FU |title=Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18007–10 |year= 1998 |pmid= 9660753 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Pirkl F, Buchner J |title=Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. |journal=J. Mol. Biol. |volume=308 |issue= 4 |pages= 795–806 |year= 2001 |pmid= 11350175 |doi= 10.1006/jmbi.2001.4595
*cite journal | author=Davies TH, Ning YM, Sánchez ER |title=A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4597–600 |year= 2002 |pmid= 11751894 |doi= 10.1074/jbc.C100531200
*cite journal | author=Giraudier S, Chagraoui H, Komura E, "et al." |title=Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors. |journal=Blood |volume=100 |issue= 8 |pages= 2932–40 |year= 2002 |pmid= 12351405 |doi= 10.1182/blood-2002-02-0485
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sinars CR, Cheung-Flynn J, Rimerman RA, "et al." |title=Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 868–73 |year= 2003 |pmid= 12538866 |doi= 10.1073/pnas.0231020100
*cite journal | author=Hubler TR, Denny WB, Valentine DL, "et al." |title=The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness. |journal=Endocrinology |volume=144 |issue= 6 |pages= 2380–7 |year= 2003 |pmid= 12746298 |doi=
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086

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