WNK lysine deficient protein kinase 1, also known as WNK1, is a human gene.cite web | title = Entrez Gene: WNK1 WNK lysine deficient protein kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65125| accessdate = ]

section_title =
summary_text = The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron. [supplied by OMIM] cite web | title = Entrez Gene: WNK1 WNK lysine deficient protein kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65125| accessdate = ]


Further reading

citations =
*cite journal | author=Hart GW, Haltiwanger RS, Holt GD, Kelly WG |title=Nucleoplasmic and cytoplasmic glycoproteins. |journal=Ciba Found. Symp. |volume=145 |issue= |pages= 102–12, discussion 112–8 |year= 1989 |pmid= 2507249 |doi=
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Xu BE, Lee BH, Min X, "et al." |title=WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. |journal=Cell Res. |volume=15 |issue= 1 |pages= 6–10 |year= 2005 |pmid= 15686619 |doi= 10.1038/sj.cr.7290256
*cite journal | author=Subramanya AR, Yang CL, McCormick JA, Ellison DH |title=WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron. |journal=Kidney Int. |volume=70 |issue= 4 |pages= 630–4 |year= 2006 |pmid= 16820787 |doi= 10.1038/sj.ki.5001634
*cite journal | author=Huang CL, Kuo E |title=Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension. |journal=Nature clinical practice. Nephrology |volume=3 |issue= 11 |pages= 623–30 |year= 2007 |pmid= 17957199 |doi= 10.1038/ncpneph0638
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Nagase T, Ishikawa K, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=
*cite journal | author=Moore TM, Garg R, Johnson C, "et al." |title=PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4311–22 |year= 2000 |pmid= 10660600 |doi=
*cite journal | author=Disse-Nicodème S, Achard JM, Desitter I, "et al." |title=A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension. |journal=Am. J. Hum. Genet. |volume=67 |issue= 2 |pages= 302–10 |year= 2000 |pmid= 10869238 |doi=
*cite journal | author=Wilson FH, Disse-Nicodème S, Choate KA, "et al." |title=Human hypertension caused by mutations in WNK kinases. |journal=Science |volume=293 |issue= 5532 |pages= 1107–12 |year= 2001 |pmid= 11498583 |doi= 10.1126/science.1062844
*cite journal | author=Veríssimo F, Jordan P |title=WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. |journal=Oncogene |volume=20 |issue= 39 |pages= 5562–9 |year= 2001 |pmid= 11571656 |doi= 10.1038/sj.onc.1204726
*cite journal | author=Xu BE, Min X, Stippec S, "et al." |title=Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48456–62 |year= 2003 |pmid= 12374799 |doi= 10.1074/jbc.M207917200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vitari AC, Deak M, Collins BJ, "et al." |title=WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. |journal=Biochem. J. |volume=378 |issue= Pt 1 |pages= 257–68 |year= 2004 |pmid= 14611643 |doi= 10.1042/BJ20031692
*cite journal | author=Delaloy C, Lu J, Houot AM, "et al." |title=Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. |journal=Mol. Cell. Biol. |volume=23 |issue= 24 |pages= 9208–21 |year= 2004 |pmid= 14645531 |doi=
*cite journal | author=Xu BE, Stippec S, Lenertz L, "et al." |title=WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7826–31 |year= 2004 |pmid= 14681216 |doi= 10.1074/jbc.M313465200
*cite journal | author=Fu GK, Wang JT, Yang J, "et al." |title=Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. |journal=Genomics |volume=84 |issue= 1 |pages= 205–10 |year= 2005 |pmid= 15203218 |doi= 10.1016/j.ygeno.2004.01.011
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051

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