Replication factor C (activator 1) 1, 145kDa, also known as RFC1, is a human gene.cite web | title = Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5981| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability.cite web | title = Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5981| accessdate = ]


Further reading

citations =
*cite journal | author=Lu Y, Riegel AT |title=The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA. |journal=Gene |volume=145 |issue= 2 |pages= 261–5 |year= 1994 |pmid= 7914507 |doi=
*cite journal | author=Luckow B, Bunz F, Stillman B, "et al." |title=Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans. |journal=Mol. Cell. Biol. |volume=14 |issue= 3 |pages= 1626–34 |year= 1994 |pmid= 8114700 |doi=
*cite journal | author=Bunz F, Kobayashi R, Stillman B |title=cDNAs encoding the large subunit of human replication factor C. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11014–8 |year= 1994 |pmid= 8248204 |doi=
*cite journal | author=Lu Y, Zeft AS, Riegel AT |title=Cloning and expression of a novel human DNA binding protein, PO-GA. |journal=Biochem. Biophys. Res. Commun. |volume=193 |issue= 2 |pages= 779–86 |year= 1993 |pmid= 8512577 |doi= 10.1006/bbrc.1993.1693
*cite journal | author=Uhlmann F, Cai J, Flores-Rozas H, "et al." |title=In vitro reconstitution of human replication factor C from its five subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6521–6 |year= 1996 |pmid= 8692848 |doi=
*cite journal | author=Fotedar R, Mossi R, Fitzgerald P, "et al." |title=A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells. |journal=EMBO J. |volume=15 |issue= 16 |pages= 4423–33 |year= 1996 |pmid= 8861969 |doi=
*cite journal | author=Uchiumi F, Ohta T, Tanuma S |title=Replication factor C recognizes 5'-phosphate ends of telomeres. |journal=Biochem. Biophys. Res. Commun. |volume=229 |issue= 1 |pages= 310–5 |year= 1997 |pmid= 8954124 |doi=
*cite journal | author=Mossi R, Jónsson ZO, Allen BL, "et al." |title=Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1769–76 |year= 1997 |pmid= 8999859 |doi=
*cite journal | author=Cujec TP, Cho H, Maldonado E, "et al." |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817–23 |year= 1997 |pmid= 9121429 |doi=
*cite journal | author=Ubeda M, Habener JF |title=The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19562–8 |year= 1997 |pmid= 9235961 |doi=
*cite journal | author=Rhéaume E, Cohen LY, Uhlmann F, "et al." |title=The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis. |journal=EMBO J. |volume=16 |issue= 21 |pages= 6346–54 |year= 1998 |pmid= 9351817 |doi= 10.1093/emboj/16.21.6346
*cite journal | author=Ellison V, Stillman B |title=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5979–87 |year= 1998 |pmid= 9488738 |doi=
*cite journal | author=Coll JM, Hickey RJ, Cronkey EA, "et al." |title=Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome. |journal=Oncol. Res. |volume=9 |issue= 11-12 |pages= 629–39 |year= 1998 |pmid= 9563011 |doi=
*cite journal | author=Allen BL, Uhlmann F, Gaur LK, "et al." |title=DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C. |journal=Nucleic Acids Res. |volume=26 |issue= 17 |pages= 3877–82 |year= 1998 |pmid= 9705493 |doi=
*cite journal | author=van der Kuip H, Carius B, Haque SJ, "et al." |title=The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins. |journal=J. Mol. Med. |volume=77 |issue= 4 |pages= 386–92 |year= 1999 |pmid= 10353443 |doi=
*cite journal | author=Wang Y, Cortez D, Yazdi P, "et al." |title=BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. |journal=Genes Dev. |volume=14 |issue= 8 |pages= 927–39 |year= 2000 |pmid= 10783165 |doi=
*cite journal | author=Yazdi PT, Wang Y, Zhao S, "et al." |title=SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. |journal=Genes Dev. |volume=16 |issue= 5 |pages= 571–82 |year= 2002 |pmid= 11877377 |doi= 10.1101/gad.970702
*cite journal | author=Anderson LA, Perkins ND |title=The large subunit of replication factor C interacts with the histone deacetylase, HDAC1. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29550–4 |year= 2002 |pmid= 12045192 |doi= 10.1074/jbc.M200513200
*cite journal | author=Ohta S, Shiomi Y, Sugimoto K, "et al." |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362–7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200
*cite journal | author=Maruyama T, Farina A, Dey A, "et al." |title=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6509–20 |year= 2002 |pmid= 12192049 |doi=

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