Tumor protein p53 binding protein, 2, also known as TP53BP2, is a human gene.cite web | title = Entrez Gene: TP53BP2 tumor protein p53 binding protein, 2| url =| accessdate = ]

section_title =
summary_text = This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: TP53BP2 tumor protein p53 binding protein, 2| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Liu ZJ, Lu X, Zhong S |title=ASPP--Apoptotic specific regulator of p53. |journal=Biochim. Biophys. Acta |volume=1756 |issue= 1 |pages= 77–80 |year= 2005 |pmid= 16139958 |doi= 10.1016/j.bbcan.2005.08.002
*cite journal | author=Iwabuchi K, Bartel PL, Li B, "et al." |title=Two cellular proteins that bind to wild-type but not mutant p53. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 13 |pages= 6098–102 |year= 1994 |pmid= 8016121 |doi=
*cite journal | author=Helps NR, Barker HM, Elledge SJ, Cohen PT |title=Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. |journal=FEBS Lett. |volume=377 |issue= 3 |pages= 295–300 |year= 1996 |pmid= 8549741 |doi= 10.1016/0014-5793(95)01347-4
*cite journal | author=Naumovski L, Cleary ML |title=The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M. |journal=Mol. Cell. Biol. |volume=16 |issue= 7 |pages= 3884–92 |year= 1996 |pmid= 8668206 |doi=
*cite journal | author=Gorina S, Pavletich NP |title=Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. |journal=Science |volume=274 |issue= 5289 |pages= 1001–5 |year= 1996 |pmid= 8875926 |doi=
*cite journal | author=Pirozzi G, McConnell SJ, Uveges AJ, "et al." |title=Identification of novel human WW domain-containing proteins by cloning of ligand targets. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14611–6 |year= 1997 |pmid= 9169421 |doi=
*cite journal | author=Yang JP, Ono T, Sonta S, "et al." |title=Assignment of p53 binding protein (TP53BP2) to human chromosome band 1q42.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=78 |issue= 1 |pages= 61–2 |year= 1997 |pmid= 9345910 |doi=
*cite journal | author=Iwabuchi K, Li B, Massa HF, "et al." |title=Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26061–8 |year= 1998 |pmid= 9748285 |doi=
*cite journal | author=Yang JP, Hori M, Takahashi N, "et al." |title=NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2. |journal=Oncogene |volume=18 |issue= 37 |pages= 5177–86 |year= 1999 |pmid= 10498867 |doi= 10.1038/sj.onc.1202904
*cite journal | author=Scanlan MJ, Gordan JD, Williamson B, "et al." |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=
*cite journal | author=Mori T, Okamoto H, Takahashi N, "et al." |title=Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines. |journal=FEBS Lett. |volume=465 |issue= 2-3 |pages= 124–8 |year= 2000 |pmid= 10631318 |doi=
*cite journal | author=Nakagawa H, Koyama K, Murata Y, "et al." |title=APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. |journal=Cancer Res. |volume=60 |issue= 1 |pages= 101–5 |year= 2000 |pmid= 10646860 |doi=
*cite journal | author=Lopez CD, Ao Y, Rohde LH, "et al." |title=Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53. |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8018–25 |year= 2000 |pmid= 11027272 |doi=
*cite journal | author=Espanel X, Sudol M |title=Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14514–23 |year= 2001 |pmid= 11278422 |doi= 10.1074/jbc.M008568200
*cite journal | author=Kajkowski EM, Lo CF, Ning X, "et al." |title=beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 18748–56 |year= 2001 |pmid= 11278849 |doi= 10.1074/jbc.M011161200
*cite journal | author=Samuels-Lev Y, O'Connor DJ, Bergamaschi D, "et al." |title=ASPP proteins specifically stimulate the apoptotic function of p53. |journal=Mol. Cell |volume=8 |issue= 4 |pages= 781–94 |year= 2001 |pmid= 11684014 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chen Y, Liu W, Naumovski L, Neve RL |title=ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. |journal=J. Neurochem. |volume=85 |issue= 3 |pages= 801–9 |year= 2003 |pmid= 12694406 |doi=
*cite journal | author=Bergamaschi D, Samuels Y, Jin B, "et al." |title=ASPP1 and ASPP2: common activators of p53 family members. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1341–50 |year= 2004 |pmid= 14729977 |doi=
*cite journal | author=Takahashi N, Kobayashi S, Jiang X, "et al." |title=Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing. |journal=Biochem. Biophys. Res. Commun. |volume=315 |issue= 2 |pages= 434–8 |year= 2004 |pmid= 14766226 |doi= 10.1016/j.bbrc.2004.01.079

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  • p53 — For the band and album of the same name, see P53 (band) and P53 (album). Tumor protein p53 PDB rendering based on 1TUP …   Wikipedia

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