Trefoil factor 3

Trefoil factor 3 (intestinal), also known as TFF3, is a human gene.cite web | title = Entrez Gene: TFF3 trefoil factor 3 (intestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7033| accessdate = ]

PBB_Summary
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summary_text = Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.cite web | title = Entrez Gene: TFF3 trefoil factor 3 (intestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7033| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hoffmann W, Jagla W, Wiede A |title=Molecular medicine of TFF-peptides: from gut to brain. |journal=Histol. Histopathol. |volume=16 |issue= 1 |pages= 319–34 |year= 2001 |pmid= 11193208 |doi=
*cite journal | author=Hoffmann W, Jagla W |title=Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain. |journal=Int. Rev. Cytol. |volume=213 |issue= |pages= 147–81 |year= 2002 |pmid= 11837892 |doi=
*cite journal | author=Langer G, Jagla W, Behrens-Baumann W, "et al." |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313–6 |year= 2003 |pmid= 12613926 |doi=
*cite journal | author=Seib T, Dooley S, Welter C |title=Characterization of the genomic structure and the promoter region of the human intestinal trefoil factor. |journal=Biochem. Biophys. Res. Commun. |volume=214 |issue= 1 |pages= 195–9 |year= 1995 |pmid= 7669039 |doi= 10.1006/bbrc.1995.2274
*cite journal | author=Thim L, Wöldike HF, Nielsen PF, "et al." |title=Characterization of human and rat intestinal trefoil factor produced in yeast. |journal=Biochemistry |volume=34 |issue= 14 |pages= 4757–64 |year= 1995 |pmid= 7718582 |doi=
*cite journal | author=Hauser F, Poulsom R, Chinery R, "et al." |title=hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 15 |pages= 6961–5 |year= 1993 |pmid= 8346203 |doi=
*cite journal | author=Podolsky DK, Lynch-Devaney K, Stow JL, "et al." |title=Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion. |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6694–702 |year= 1993 |pmid= 8454642 |doi=
*cite journal | author=Schmitt H, Wundrack I, Beck S, "et al." |title=A third P-domain peptide gene (TFF3), human intestinal trefoil factor, maps to 21q22.3. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 4 |pages= 299–302 |year= 1996 |pmid= 8641134 |doi=
*cite journal | author=Chinery R, Williamson J, Poulsom R |title=The gene encoding human intestinal trefoil factor (TFF3) is located on chromosome 21q22.3 clustered with other members of the trefoil peptide family. |journal=Genomics |volume=32 |issue= 2 |pages= 281–4 |year= 1997 |pmid= 8833157 |doi= 10.1006/geno.1996.0117
*cite journal | author=Probst JC, Zetzsche T, Weber M, "et al." |title=Human intestinal trefoil factor is expressed in human hypothalamus and pituitary: evidence for a novel neuropeptide. |journal=FASEB J. |volume=10 |issue= 13 |pages= 1518–23 |year= 1997 |pmid= 8940297 |doi=
*cite journal | author=Gött P, Beck S, Machado JC, "et al." |title=Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. |journal=Eur. J. Hum. Genet. |volume=4 |issue= 6 |pages= 308–15 |year= 1997 |pmid= 9043862 |doi=
*cite journal | author=Seib T, Blin N, Hilgert K, "et al." |title=The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. |journal=Genomics |volume=40 |issue= 1 |pages= 200–2 |year= 1997 |pmid= 9070946 |doi= 10.1006/geno.1996.4511
*cite journal | author=Tan XD, Liu QP, Hsueh W, "et al." |title=Intestinal trefoil factor binds to intestinal epithelial cells and induces nitric oxide production: priming and enhancing effects of mucin. |journal=Biochem. J. |volume=338 ( Pt 3) |issue= |pages= 745–51 |year= 1999 |pmid= 10051448 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Berry A, Scott HS, Kudoh J, "et al." |title=Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region. |journal=Genomics |volume=68 |issue= 1 |pages= 22–9 |year= 2001 |pmid= 10950923 |doi= 10.1006/geno.2000.6253
*cite journal | author=Wiede A, Hinz M, Canzler E, "et al." |title=Synthesis and localization of the mucin-associated TFF-peptides in the human uterus. |journal=Cell Tissue Res. |volume=303 |issue= 1 |pages= 109–15 |year= 2001 |pmid= 11235998 |doi=
*cite journal | author=Yamachika T, Werther JL, Bodian C, "et al." |title=Intestinal trefoil factor: a marker of poor prognosis in gastric carcinoma. |journal=Clin. Cancer Res. |volume=8 |issue= 5 |pages= 1092–9 |year= 2002 |pmid= 12006524 |doi=
*cite journal | author=Kimura Y, Leung PS, Kenny TP, "et al." |title=Differential expression of intestinal trefoil factor in biliary epithelial cells of primary biliary cirrhosis. |journal=Hepatology |volume=36 |issue= 5 |pages= 1227–35 |year= 2002 |pmid= 12395334 |doi= 10.1053/jhep.2002.36157

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