Myeloproliferative leukemia virus oncogene

Myeloproliferative leukemia virus oncogene (MPL) also known as CD110 (Cluster of Differentiation 110), is a human gene.cite web | title = Entrez Gene: MPL myeloproliferative leukemia virus oncogene| url =| accessdate = ]

section_title =
summary_text = In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.cite web | title = Entrez Gene: MPL myeloproliferative leukemia virus oncogene| url =| accessdate = ]

ee also

* Cluster of differentiation


Further reading

citations =
*cite journal | author=Kato T, Matsumoto A, Ogami K, "et al." |title=Native thrombopoietin: structure and function. |journal=Stem Cells |volume=16 |issue= 5 |pages= 322–8 |year= 1999 |pmid= 9766811 |doi=
*cite journal | author=Vigon I, Mornon JP, Cocault L, "et al." |title=Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5640–4 |year= 1992 |pmid= 1608974 |doi=
*cite journal | author=Souyri M, Vigon I, Penciolelli JF, "et al." |title=A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. |journal=Cell |volume=63 |issue= 6 |pages= 1137–47 |year= 1991 |pmid= 2175677 |doi=
*cite journal | author=Le Coniat M, Souyri M, Vigon I, "et al." |title=The human homolog of the myeloproliferative virus maps to chromosome band 1p34. |journal=Hum. Genet. |volume=83 |issue= 2 |pages= 194–6 |year= 1989 |pmid= 2550356 |doi=
*cite journal | author=Drachman JG, Griffin JD, Kaushansky K |title=The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. |journal=J. Biol. Chem. |volume=270 |issue= 10 |pages= 4979–82 |year= 1995 |pmid= 7534285 |doi=
*cite journal | author=Mignotte V, Vigon I, Boucher de Crèvecoeur E, "et al." |title=Structure and transcription of the human c-mpl gene (MPL). |journal=Genomics |volume=20 |issue= 1 |pages= 5–12 |year= 1994 |pmid= 8020956 |doi=
*cite journal | author=Mu SX, Xia M, Elliott G, "et al." |title=Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells. |journal=Blood |volume=86 |issue= 12 |pages= 4532–43 |year= 1996 |pmid= 8541543 |doi=
*cite journal | author=Deveaux S, Filipe A, Lemarchandel V, "et al." |title=Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes. |journal=Blood |volume=87 |issue= 11 |pages= 4678–85 |year= 1996 |pmid= 8639837 |doi=
*cite journal | author=Drachman JG, Kaushansky K |title=Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2350–5 |year= 1997 |pmid= 9122198 |doi=
*cite journal | author=Ihara K, Ishii E, Eguchi M, "et al." |title=Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 3132–6 |year= 1999 |pmid= 10077649 |doi=
*cite journal | author=Drachman JG, Millett KM, Kaushansky K |title=Thrombopoietin signal transduction requires functional JAK2, not TYK2. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13480–4 |year= 1999 |pmid= 10224114 |doi=
*cite journal | author=Cargill M, Altshuler D, Ireland J, "et al." |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231–8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290
*cite journal | author=Okabe S, Tauchi T, Morita H, "et al." |title=Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. |journal=Exp. Hematol. |volume=27 |issue= 10 |pages= 1542–7 |year= 1999 |pmid= 10517496 |doi=
*cite journal | author=Miyakawa Y, Drachman JG, Gallis B, "et al." |title=A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32214–9 |year= 2000 |pmid= 10918061 |doi= 10.1074/jbc.M005080200
*cite journal | author=van den Oudenrijn S, Bruin M, Folman CC, "et al." |title=Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia. |journal=Br. J. Haematol. |volume=110 |issue= 2 |pages= 441–8 |year= 2000 |pmid= 10971406 |doi=
*cite journal | author=Wang Q, Miyakawa Y, Fox N, Kaushansky K |title=Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1. |journal=Blood |volume=96 |issue= 6 |pages= 2093–9 |year= 2000 |pmid= 10979953 |doi=
*cite journal | author=Miyakawa Y, Rojnuckarin P, Habib T, Kaushansky K |title=Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2494–502 |year= 2001 |pmid= 11054408 |doi= 10.1074/jbc.M002633200
*cite journal | author=Tonelli R, Scardovi AL, Pession A, "et al." |title=Compound heterozygosity for two different amino-acid substitution mutations in the thrombopoietin receptor (c-mpl gene) in congenital amegakaryocytic thrombocytopenia (CAMT). |journal=Hum. Genet. |volume=107 |issue= 3 |pages= 225–33 |year= 2000 |pmid= 11071383 |doi=
*cite journal | author=Ballmaier M, Germeshausen M, Schulze H, "et al." |title=c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia. |journal=Blood |volume=97 |issue= 1 |pages= 139–46 |year= 2001 |pmid= 11133753 |doi=

External links


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