Glycophorin A (MNS blood group), also known as GYPA, is a human gene.cite web | title = Entrez Gene: GYPA glycophorin A (MNS blood group)| url =| accessdate = ] GYPA has also recently been designated CD235a (cluster of differentiation 235a).

section_title =
summary_text = Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPA gene consists of 7 exons and has 97% sequence homology with GYPB from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.cite web | title = Entrez Gene: GYPA glycophorin A (MNS blood group)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Blumenfeld OO, Huang CH |title=Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: multiple gene rearrangements and modulation of splice site usage result in extensive diversification. |journal=Hum. Mutat. |volume=6 |issue= 3 |pages= 199–209 |year= 1996 |pmid= 8535438 |doi= 10.1002/humu.1380060302
*cite journal | author=Blumenfeld OO, Huang CH |title=Molecular genetics of glycophorin MNS variants. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=4 |issue= 4 |pages= 357–65 |year= 1997 |pmid= 9269716 |doi=
*cite journal | author=Johnson ST, McFarland JG, Kelly KJ, "et al." |title=Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria-pertussis-tetanus vaccination. |journal=Transfusion |volume=42 |issue= 5 |pages= 567–71 |year= 2002 |pmid= 12084164 |doi=
*cite journal | author=Tomita M, Marchesi VT |title=Amino-acid sequence and oligosaccharide attachment sites of human erythrocyte glycophorin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=72 |issue= 8 |pages= 2964–8 |year= 1976 |pmid= 1059087 |doi=
*cite journal | author=Lemmon MA, Flanagan JM, Hunt JF, "et al." |title=Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7683–9 |year= 1992 |pmid= 1560003 |doi=
*cite journal | author=Huang CH, Spruell P, Moulds JJ, Blumenfeld OO |title=Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype. |journal=Blood |volume=80 |issue= 1 |pages= 257–63 |year= 1992 |pmid= 1611092 |doi=
*cite journal | author=Huang CH, Kikuchi M, McCreary J, Blumenfeld OO |title=Gene conversion confined to a direct repeat of the acceptor splice site generates allelic diversity at human glycophorin (GYP) locus. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3336–42 |year= 1992 |pmid= 1737789 |doi=
*cite journal | author=Barton P, Collins A, Hoogenraad N |title=A variant of glycophorin A resulting from the deletion of exon 4. |journal=Biochim. Biophys. Acta |volume=1090 |issue= 2 |pages= 265–6 |year= 1991 |pmid= 1932122 |doi=
*cite journal | author=Huang CH, Blumenfeld OO |title=Identification of recombination events resulting in three hybrid genes encoding human MiV, MiV(J.L.), and Sta glycophorins. |journal=Blood |volume=77 |issue= 8 |pages= 1813–20 |year= 1991 |pmid= 2015404 |doi=
*cite journal | author=Huang CH, Blumenfeld OO |title=Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification. |journal=J. Biol. Chem. |volume=266 |issue= 11 |pages= 7248–55 |year= 1991 |pmid= 2016325 |doi=
*cite journal | author=Hamid J, Burness AT |title=The mechanism of production of multiple mRNAs for human glycophorin A. |journal=Nucleic Acids Res. |volume=18 |issue= 19 |pages= 5829–36 |year= 1990 |pmid= 2216775 |doi=
*cite journal | author=Dill K, Hu SH, Berman E, "et al." |title=One- and two-dimensional NMR studies of the N-terminal portion of glycophorin A at 11.7 Tesla. |journal=J. Protein Chem. |volume=9 |issue= 2 |pages= 129–36 |year= 1990 |pmid= 2386609 |doi=
*cite journal | author=Kudo S, Fukuda M |title=Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 12 |pages= 4619–23 |year= 1989 |pmid= 2734312 |doi=
*cite journal | author=Matsui Y, Natori S, Obinata M |title=Isolation of the cDNA clone for mouse glycophorin, erythroid-specific membrane protein. |journal=Gene |volume=77 |issue= 2 |pages= 325–32 |year= 1989 |pmid= 2753361 |doi=
*cite journal | author=Vignal A, Rahuel C, el Maliki B, "et al." |title=Molecular analysis of glycophorin A and B gene structure and expression in homozygous Miltenberger class V (Mi. V) human erythrocytes. |journal=Eur. J. Biochem. |volume=184 |issue= 2 |pages= 337–44 |year= 1989 |pmid= 2792104 |doi=
*cite journal | author=Tate CG, Tanner MJ |title=Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta. |journal=Biochem. J. |volume=254 |issue= 3 |pages= 743–50 |year= 1988 |pmid= 3196288 |doi=
*cite journal | author=Huang CH, Puglia KV, Bigbee WL, "et al." |title=A family study of multiple mutations of alpha and delta glycophorins (glycophorins A and B). |journal=Hum. Genet. |volume=81 |issue= 1 |pages= 26–30 |year= 1989 |pmid= 3198123 |doi=
*cite journal | author=Rahuel C, London J, d'Auriol L, "et al." |title=Characterization of cDNA clones for human glycophorin A. Use for gene localization and for analysis of normal of glycophorin-A-deficient (Finnish type) genomic DNA. |journal=Eur. J. Biochem. |volume=172 |issue= 1 |pages= 147–53 |year= 1988 |pmid= 3345758 |doi=
*cite journal | author=Siebert PD, Fukuda M |title=Isolation and characterization of human glycophorin A cDNA clones by a synthetic oligonucleotide approach: nucleotide sequence and mRNA structure. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 6 |pages= 1665–9 |year= 1986 |pmid= 3456608 |doi=
*cite journal | author=Siebert PD, Fukuda M |title=Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 19 |pages= 6735–9 |year= 1987 |pmid= 3477806 |doi=

External links


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