General transcription factor II, i, also known as GTF2I, is a human gene.cite web | title = Entrez Gene: GTF2I general transcription factor II, i| url =| accessdate = ]

section_title =
summary_text = This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5' UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants.cite web | title = Entrez Gene: GTF2I general transcription factor II, i| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Roy AL, Meisterernst M, Pognonec P, Roeder RG |title=Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF. |journal=Nature |volume=354 |issue= 6350 |pages= 245–8 |year= 1992 |pmid= 1961251 |doi= 10.1038/354245a0
*cite journal | author=Roy AL, Carruthers C, Gutjahr T, Roeder RG |title=Direct role for Myc in transcription initiation mediated by interactions with TFII-I. |journal=Nature |volume=365 |issue= 6444 |pages= 359–61 |year= 1993 |pmid= 8377829 |doi= 10.1038/365359a0
*cite journal | author=Yang W, Desiderio S |title=BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 2 |pages= 604–9 |year= 1997 |pmid= 9012831 |doi=
*cite journal | author=Grueneberg DA, Henry RW, Brauer A, "et al." |title=A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I. |journal=Genes Dev. |volume=11 |issue= 19 |pages= 2482–93 |year= 1997 |pmid= 9334314 |doi=
*cite journal | author=Roy AL, Du H, Gregor PD, "et al." |title=Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1. |journal=EMBO J. |volume=16 |issue= 23 |pages= 7091–104 |year= 1998 |pmid= 9384587 |doi= 10.1093/emboj/16.23.7091
*cite journal | author=Pérez Jurado LA, Wang YK, Peoples R, "et al." |title=A duplicated gene in the breakpoint regions of the 7q11.23 Williams-Beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTK. |journal=Hum. Mol. Genet. |volume=7 |issue= 3 |pages= 325–34 |year= 1998 |pmid= 9466987 |doi=
*cite journal | author=Kim DW, Cheriyath V, Roy AL, Cochran BH |title=TFII-I enhances activation of the c-fos promoter through interactions with upstream elements. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3310–20 |year= 1998 |pmid= 9584171 |doi=
*cite journal | author=Cheriyath V, Novina CD, Roy AL |title=TFII-I regulates Vbeta promoter activity through an initiator element. |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4444–54 |year= 1998 |pmid= 9671454 |doi=
*cite journal | author=Novina CD, Cheriyath V, Roy AL |title=Regulation of TFII-I activity by phosphorylation. |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33443–8 |year= 1999 |pmid= 9837922 |doi=
*cite journal | author=Novina CD, Kumar S, Bajpai U, "et al." |title=Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5014–24 |year= 1999 |pmid= 10373551 |doi=
*cite journal | author=Kim DW, Cochran BH |title=Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter. |journal=Mol. Cell. Biol. |volume=20 |issue= 4 |pages= 1140–8 |year= 2000 |pmid= 10648599 |doi=
*cite journal | author=Cheriyath V, Roy AL |title=Alternatively spliced isoforms of TFII-I. Complex formation, nuclear translocation, and differential gene regulation. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26300–8 |year= 2000 |pmid= 10854432 |doi= 10.1074/jbc.M002980200
*cite journal | author=Parker R, Phan T, Baumeister P, "et al." |title=Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6. |journal=Mol. Cell. Biol. |volume=21 |issue= 9 |pages= 3220–33 |year= 2001 |pmid= 11287625 |doi= 10.1128/MCB.21.9.3220-3233.2001
*cite journal | author=Kim DW, Cochran BH |title=JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase. |journal=Mol. Cell. Biol. |volume=21 |issue= 10 |pages= 3387–97 |year= 2001 |pmid= 11313464 |doi= 10.1128/MCB.21.10.3387-3397.2000
*cite journal | author=Egloff AM, Desiderio S |title=Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 27806–15 |year= 2001 |pmid= 11373296 |doi= 10.1074/jbc.M103692200
*cite journal | author=Cheriyath V, Desgranges ZP, Roy AL |title=c-Src-dependent transcriptional activation of TFII-I. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22798–805 |year= 2002 |pmid= 11934902 |doi= 10.1074/jbc.M202956200
*cite journal | author=Casteel DE, Zhuang S, Gudi T, "et al." |title=cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 32003–14 |year= 2002 |pmid= 12082086 |doi= 10.1074/jbc.M112332200
*cite journal | author=Tussie-Luna MI, Michel B, Hakre S, Roy AL |title=The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43185–93 |year= 2003 |pmid= 12193603 |doi= 10.1074/jbc.M207635200
*cite journal | author=Tussié-Luna MI, Bayarsaihan D, Seto E, "et al." |title=Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 12807–12 |year= 2002 |pmid= 12239342 |doi= 10.1073/pnas.192464499
*cite journal | author=Wen YD, Cress WD, Roy AL, Seto E |title=Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1841–7 |year= 2003 |pmid= 12393887 |doi= 10.1074/jbc.M206528200

External links


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