CD82 (gene)

CD82 (Cluster of Differentiation 82) is a human protein encoded by the gene|CD82 gene.cite web | title = Entrez Gene: CD82 CD82 molecule| url =| accessdate = ]

section_title =
summary_text = This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.cite web | title = Entrez Gene: CD82 CD82 molecule| url =| accessdate = ]

ee also

* Cluster of differentiation


Further reading

citations =
*cite journal | author=Baek SH |title=A novel link between SUMO modification and cancer metastasis. |journal=Cell Cycle |volume=5 |issue= 14 |pages= 1492–5 |year= 2006 |pmid= 16861889 |doi=
*cite journal | author=Imai T, Fukudome K, Takagi S, "et al." |title=C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. |journal=J. Immunol. |volume=149 |issue= 9 |pages= 2879–86 |year= 1992 |pmid= 1401919 |doi=
*cite journal | author=Ichikawa T, Ichikawa Y, Dong J, "et al." |title=Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. |journal=Cancer Res. |volume=52 |issue= 12 |pages= 3486–90 |year= 1992 |pmid= 1596907 |doi=
*cite journal | author=Gaugitsch HW, Hofer E, Huber NE, "et al." |title=A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23. |journal=Eur. J. Immunol. |volume=21 |issue= 2 |pages= 377–83 |year= 1991 |pmid= 1842498 |doi=
*cite journal | author=Ichikawa T, Ichikawa Y, Isaacs JT |title=Genetic factors and suppression of metastatic ability of prostatic cancer. |journal=Cancer Res. |volume=51 |issue= 14 |pages= 3788–92 |year= 1991 |pmid= 2065333 |doi=
*cite journal | author=Imai T, Kakizaki M, Nishimura M, Yoshie O |title=Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. |journal=J. Immunol. |volume=155 |issue= 3 |pages= 1229–39 |year= 1995 |pmid= 7636191 |doi=
*cite journal | author=Dong JT, Lamb PW, Rinker-Schaeffer CW, "et al." |title=KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. |journal=Science |volume=268 |issue= 5212 |pages= 884–6 |year= 1995 |pmid= 7754374 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Mannion BA, Berditchevski F, Kraeft SK, "et al." |title=Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). |journal=J. Immunol. |volume=157 |issue= 5 |pages= 2039–47 |year= 1996 |pmid= 8757325 |doi=
*cite journal | author=Szöllósi J, Horejsí V, Bene L, "et al." |title=Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. |journal=J. Immunol. |volume=157 |issue= 7 |pages= 2939–46 |year= 1996 |pmid= 8816400 |doi=
*cite journal | author=Dong JT, Isaacs WB, Barrett JC, Isaacs JT |title=Genomic organization of the human KAI1 metastasis-suppressor gene. |journal=Genomics |volume=41 |issue= 1 |pages= 25–32 |year= 1997 |pmid= 9126478 |doi= 10.1006/geno.1997.4618
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hammond C, Denzin LK, Pan M, "et al." |title=The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. |journal=J. Immunol. |volume=161 |issue= 7 |pages= 3282–91 |year= 1998 |pmid= 9759843 |doi=
*cite journal | author=Horváth G, Serru V, Clay D, "et al." |title=CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30537–43 |year= 1998 |pmid= 9804823 |doi=
*cite journal | author=Serru V, Le Naour F, Billard M, "et al." |title=Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. |journal=Biochem. J. |volume=340 ( Pt 1) |issue= |pages= 103–11 |year= 1999 |pmid= 10229664 |doi=
*cite journal | author=Lombardi DP, Geradts J, Foley JF, "et al." |title=Loss of KAI1 expression in the progression of colorectal cancer. |journal=Cancer Res. |volume=59 |issue= 22 |pages= 5724–31 |year= 1999 |pmid= 10582691 |doi=
*cite journal | author=Shibagaki N, Hanada K, Yamashita H, "et al." |title=Overexpression of CD82 on human T cells enhances LFA-1 / ICAM-1-mediated cell-cell adhesion: functional association between CD82 and LFA-1 in T cell activation. |journal=Eur. J. Immunol. |volume=29 |issue= 12 |pages= 4081–91 |year= 2000 |pmid= 10602019 |doi=
*cite journal | author=Nakamura K, Mitamura T, Takahashi T, "et al." |title=Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18284–90 |year= 2000 |pmid= 10749879 |doi= 10.1074/jbc.M907971199
*cite journal | author=Odintsova E, Sugiura T, Berditchevski F |title=Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. |journal=Curr. Biol. |volume=10 |issue= 16 |pages= 1009–12 |year= 2001 |pmid= 10985391 |doi=
*cite journal | author=Ono M, Handa K, Withers DA, Hakomori S |title=Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 744–50 |year= 2001 |pmid= 11162423 |doi= 10.1006/bbrc.2000.4030

External links


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