Sjogren syndrome antigen B

Sjogren syndrome antigen B (autoantigen La), also known as SSB, is a human gene.cite web | title = Entrez Gene: SSB Sjogren syndrome antigen B (autoantigen La)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6741| accessdate = ]

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summary_text = La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006). [supplied by OMIM] cite web | title = Entrez Gene: SSB Sjogren syndrome antigen B (autoantigen La)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6741| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kohsaka H, Yamamoto K, Fujii H, "et al." |title=Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein. |journal=J. Clin. Invest. |volume=85 |issue= 5 |pages= 1566–74 |year= 1990 |pmid= 1692037 |doi=
*cite journal | author=Sturgess AD, Peterson MG, McNeilage LJ, "et al." |title=Characteristics and epitope mapping of a cloned human autoantigen La. |journal=J. Immunol. |volume=140 |issue= 9 |pages= 3212–8 |year= 1988 |pmid= 2452201 |doi=
*cite journal | author=Rauh AJ, Hornig H, Lührmann R |title=At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach. |journal=Eur. J. Immunol. |volume=18 |issue= 12 |pages= 2049–57 |year= 1989 |pmid= 2464497 |doi=
*cite journal | author=Chan EK, Sullivan KF, Tan EM |title=Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. |journal=Nucleic Acids Res. |volume=17 |issue= 6 |pages= 2233–44 |year= 1989 |pmid= 2468131 |doi=
*cite journal | author=Gottlieb E, Steitz JA |title=Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. |journal=EMBO J. |volume=8 |issue= 3 |pages= 851–61 |year= 1989 |pmid= 2470590 |doi=
*cite journal | author=Chambers JC, Kenan D, Martin BJ, Keene JD |title=Genomic structure and amino acid sequence domains of the human La autoantigen. |journal=J. Biol. Chem. |volume=263 |issue= 34 |pages= 18043–51 |year= 1989 |pmid= 3192525 |doi=
*cite journal | author=Chambers JC, Keene JD |title=Isolation and analysis of cDNA clones expressing human lupus La antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 7 |pages= 2115–9 |year= 1985 |pmid= 3856888 |doi=
*cite journal | author=Svitkin YV, Pause A, Sonenberg N |title=La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA. |journal=J. Virol. |volume=68 |issue= 11 |pages= 7001–7 |year= 1994 |pmid= 7933082 |doi=
*cite journal | author=Tröster H, Metzger TE, Semsei I, "et al." |title=One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome. |journal=J. Exp. Med. |volume=180 |issue= 6 |pages= 2059–67 |year= 1994 |pmid= 7964483 |doi=
*cite journal | author=Fan H, Sakulich AL, Goodier JL, "et al." |title=Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes. |journal=Cell |volume=88 |issue= 5 |pages= 707–15 |year= 1997 |pmid= 9054510 |doi=
*cite journal | author=McLaren RS, Caruccio N, Ross J |title=Human La protein: a stabilizer of histone mRNA. |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3028–36 |year= 1997 |pmid= 9154801 |doi=
*cite journal | author=Grölz D, Bachmann M |title=The nuclear autoantigen La/SS-associated antigen B: one gene, three functional mRNAs. |journal=Biochem. J. |volume=323 ( Pt 1) |issue= |pages= 151–8 |year= 1997 |pmid= 9173875 |doi=
*cite journal | author=Helsloot J, Sturgess A |title=T cell reactivity to Sjögren's syndrome related antigen La(SSB). |journal=J. Rheumatol. |volume=24 |issue= 12 |pages= 2340–7 |year= 1998 |pmid= 9415639 |doi=
*cite journal | author=Broekhuis CH, Neubauer G, van der Heijden A, "et al." |title=Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution. |journal=Biochemistry |volume=39 |issue= 11 |pages= 3023–33 |year= 2000 |pmid= 10715123 |doi=
*cite journal | author=Spångberg K, Wiklund L, Schwartz S |title=HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities. |journal=Virology |volume=274 |issue= 2 |pages= 378–90 |year= 2000 |pmid= 10964780 |doi= 10.1006/viro.2000.0461
*cite journal | author=Intine RV, Sakulich AL, Koduru SB, "et al." |title=Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 339–48 |year= 2000 |pmid= 10983981 |doi=
*cite journal | author=Nashimoto M, Nashimoto C, Tamura M, "et al." |title=The inhibitory effect of the autoantigen La on in vitro 3' processing of mammalian precursor tRNAs. |journal=J. Mol. Biol. |volume=312 |issue= 5 |pages= 975–84 |year= 2001 |pmid= 11580243 |doi= 10.1006/jmbi.2001.5026
*cite journal | author=De Nova-Ocampo M, Villegas-Sepúlveda N, del Angel RM |title=Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA. |journal=Virology |volume=295 |issue= 2 |pages= 337–47 |year= 2002 |pmid= 12033793 |doi= 10.1006/viro.2002.1407
*cite journal | author=Intine RV, Dundr M, Misteli T, Maraia RJ |title=Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs. |journal=Mol. Cell |volume=9 |issue= 5 |pages= 1113–23 |year= 2002 |pmid= 12049746 |doi=
*cite journal | author=Fouraux MA, Bouvet P, Verkaart S, "et al." |title=Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes. |journal=J. Mol. Biol. |volume=320 |issue= 3 |pages= 475–88 |year= 2002 |pmid= 12096904 |doi=

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