Trefoil factor 1

Trefoil factor 1, also known as TFF1, is a human gene.cite web | title = Entrez Gene: TFF1 trefoil factor 1| url =| accessdate = ]

section_title =
summary_text = Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.cite web | title = Entrez Gene: TFF1 trefoil factor 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Langer G, Jagla W, Behrens-Baumann W, "et al." |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313–6 |year= 2003 |pmid= 12613926 |doi=
*cite journal | author=Piggott NH, Henry JA, May FE, Westley BR |title=Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry. |journal=J. Pathol. |volume=163 |issue= 2 |pages= 95–104 |year= 1991 |pmid= 1707960 |doi= 10.1002/path.1711630204
*cite journal | author=Mori K, Fujii R, Kida N, "et al." |title=Complete primary structure of the human estrogen-responsive gene (pS2) product. |journal=J. Biochem. |volume=107 |issue= 1 |pages= 73–6 |year= 1990 |pmid= 2185238 |doi=
*cite journal | author=Tomasetto C, Rio MC, Gautier C, "et al." |title=hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. |journal=EMBO J. |volume=9 |issue= 2 |pages= 407–14 |year= 1990 |pmid= 2303034 |doi=
*cite journal | author=Takahashi H, Kida N, Fujii R, "et al." |title=Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. |journal=FEBS Lett. |volume=261 |issue= 2 |pages= 283–6 |year= 1990 |pmid= 2311759 |doi=
*cite journal | author=Rio MC, Bellocq JP, Daniel JY, "et al." |title=Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. |journal=Science |volume=241 |issue= 4866 |pages= 705–8 |year= 1988 |pmid= 3041593 |doi=
*cite journal | author=Rio MC, Lepage P, Diemunsch P, "et al." |title= [Primary structure of human protein pS2] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=307 |issue= 19 |pages= 825–31 |year= 1989 |pmid= 3146413 |doi=
*cite journal | author=Mori K, Fujii R, Kida N, "et al." |title=Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product. |journal=Biochem. Biophys. Res. Commun. |volume=155 |issue= 1 |pages= 366–72 |year= 1988 |pmid= 3261981 |doi=
*cite journal | author=Jeltsch JM, Roberts M, Schatz C, "et al." |title=Structure of the human oestrogen-responsive gene pS2. |journal=Nucleic Acids Res. |volume=15 |issue= 4 |pages= 1401–14 |year= 1987 |pmid= 3822834 |doi=
*cite journal | author=Prud'homme JF, Fridlansky F, Le Cunff M, "et al." |title=Cloning of a gene expressed in human breast cancer and regulated by estrogen in MCF-7 cells. |journal=DNA |volume=4 |issue= 1 |pages= 11–21 |year= 1985 |pmid= 3838275 |doi=
*cite journal | author=Jakowlew SB, Breathnach R, Jeltsch JM, "et al." |title=Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7. |journal=Nucleic Acids Res. |volume=12 |issue= 6 |pages= 2861–78 |year= 1984 |pmid= 6324130 |doi=
*cite journal | author=Hanby AM, Poulsom R, Singh S, "et al." |title=Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. |journal=Gastroenterology |volume=105 |issue= 4 |pages= 1110–6 |year= 1993 |pmid= 8405856 |doi=
*cite journal | author=Polshakov VI, Frenkiel TA, Westley B, "et al." |title=NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide. Similarities to porcine spasmolytic peptide and evidence for a monomeric structure. |journal=Eur. J. Biochem. |volume=233 |issue= 3 |pages= 847–55 |year= 1996 |pmid= 8521850 |doi=
*cite journal | author=Gött P, Beck S, Machado JC, "et al." |title=Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. |journal=Eur. J. Hum. Genet. |volume=4 |issue= 6 |pages= 308–15 |year= 1997 |pmid= 9043862 |doi=
*cite journal | author=Seib T, Blin N, Hilgert K, "et al." |title=The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. |journal=Genomics |volume=40 |issue= 1 |pages= 200–2 |year= 1997 |pmid= 9070946 |doi= 10.1006/geno.1996.4511
*cite journal | author=Polshakov VI, Williams MA, Gargaro AR, "et al." |title=High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein. |journal=J. Mol. Biol. |volume=267 |issue= 2 |pages= 418–32 |year= 1997 |pmid= 9096235 |doi= 10.1006/jmbi.1997.0896
*cite journal | author=Chadwick MP, Westley BR, May FE |title=Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58. |journal=Biochem. J. |volume=327 ( Pt 1) |issue= |pages= 117–23 |year= 1997 |pmid= 9355742 |doi=
*cite journal | author=Chen H, Lin RJ, Xie W, "et al." |title=Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. |journal=Cell |volume=98 |issue= 5 |pages= 675–86 |year= 1999 |pmid= 10490106 |doi=
*cite journal | author=Newton JL, Allen A, Westley BR, May FE |title=The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach. |journal=Gut |volume=46 |issue= 3 |pages= 312–20 |year= 2000 |pmid= 10673290 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518

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