Colony stimulating factor 1 receptor

Colony stimulating factor 1 receptor

Rendering based on PDB 2I0V.
Identifiers
Symbols CSF1R; C-FMS; CD115; CSFR; FIM2; FMS
External IDs OMIM164770 MGI1339758 HomoloGene3817 GeneCards: CSF1R Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE CSF1R 203104 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1436 12978
Ensembl ENSG00000182578 ENSMUSG00000024621
UniProt P07333 Q0P635
RefSeq (mRNA) NM_005211 NM_001037859.2
RefSeq (protein) NP_005202 NP_001032948.2
Location (UCSC) Chr 5:
149.43 – 149.49 Mb
Chr 18:
61.27 – 61.29 Mb
PubMed search [1] [2]

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene.[1][2] It is a receptor for a cytokine called colony stimulating factor 1.

Contents

Function

The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. The first intron of the CSFR1 gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene, oriented in the opposite direction to the CSFR1 gene.[1]

Clinical significance

Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia.[3] Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active.[4] Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.[5][6][7]


Interactions

Colony stimulating factor 1 receptor has been shown to interact with FYN,[8] Suppressor of cytokine signaling 1,[9] Grb2[10] and Cbl gene.[11]

See also

References

  1. ^ a b EntrezGene 1436
  2. ^ Galland, F.; Stefanova, M.; Lafage, M.; Birnbaum, D. (1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15ql5→q23". Cytogenetic and Genome Research 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909. 
  3. ^ Ridge, Susan A.; Worwood, Mark; Oscier, David; Jacobs, Allan; Padua, Rose Ann (1990). "FMS Mutations in Myelodysplastic, Leukemic, and Normal Subjects". Proceedings of the National Academy of Sciences 87 (4): 1377–80. doi:10.1073/pnas.87.4.1377. JSTOR 2353838. PMC 53478. PMID 2406720. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53478. 
  4. ^ Mitrasinovic, O. M.; Grattan, A; Robinson, CC; Lapustea, NB; Poon, C; Ryan, H; Phong, C; Murphy Jr, GM (2005). "Microglia Overexpressing the Macrophage Colony-Stimulating Factor Receptor Are Neuroprotective in a Microglial-Hippocampal Organotypic Coculture System". Journal of Neuroscience 25 (17): 4442–51. doi:10.1523/JNEUROSCI.0514-05.2005. PMID 15858070. 
  5. ^ Tamimi, R. M.; Brugge, J. S.; Freedman, M. L.; Miron, A.; Iglehart, J. D.; Colditz, G. A.; Hankinson, S. E. (2008). "Circulating Colony Stimulating Factor-1 and Breast Cancer Risk". Cancer Research 68 (1): 18–21. doi:10.1158/0008-5472.CAN-07-3234. PMC 2821592. PMID 18172291. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2821592. 
  6. ^ Pollard, J. W.; Hennighausen, L (1994). "Colony Stimulating Factor 1 is Required for Mammary Gland Development During Pregnancy". Proceedings of the National Academy of Sciences 91 (20): 9312–6. doi:10.1073/pnas.91.20.9312. PMC 44802. PMID 7937762. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44802. 
  7. ^ Sapi, Eva (2004). "The Role of CSF-1 in Normal Physiology of Mammary Gland and Breast Cancer: An Update". Experimental Biology and Medicine 229 (1): 1–11. PMID 14709771. http://ebm.rsmjournals.com/cgi/content/full/229/1/1. 
  8. ^ Courtneidge, SA; Dhand, R; Pilat, D; Twamley, GM; Waterfield, MD; Roussel, MF (1993). "Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor". The EMBO journal 12 (3): 943–50. PMC 413295. PMID 7681396. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=413295. 
  9. ^ Bourette, R. P.; De Sepulveda, P; Arnaud, S; Dubreuil, P; Rottapel, R; Mouchiroud, G (2001). "Suppressor of Cytokine Signaling 1 Interacts with the Macrophage Colony-stimulating Factor Receptor and Negatively Regulates Its Proliferation Signal". Journal of Biological Chemistry 276 (25): 22133–9. doi:10.1074/jbc.M101878200. PMID 11297560. 
  10. ^ Mancini, Annalisa; Niedenthal, Rainer; Joos, Hans; Koch, Alexandra; Trouliaris, Sylvia; Niemann, Heiner; Tamura, Teruko (1997). "Identification of a second Grb2 binding site in the v-Fms tyrosine kinase". Oncogene 15 (13): 1565–72. doi:10.1038/sj.onc.1201518. PMID 9380408. 
  11. ^ Mancini, A.; Koch, A; Wilms, R; Tamura, T (2002). "C-Cbl Associates Directly with the C-terminal Tail of the Receptor for the Macrophage Colony-stimulating Factor, c-Fms, and Down-modulates This Receptor but Not the Viral Oncogene v-Fms". Journal of Biological Chemistry 277 (17): 14635–40. doi:10.1074/jbc.M109214200. PMID 11847211. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.