CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a human gene.cite web | title = Entrez Gene: CD81 CD81 molecule| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies.cite web | title = Entrez Gene: CD81 CD81 molecule| url =| accessdate = ]

ee also

* Cluster of differentiation


Further reading

citations =
*cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=
*cite journal | author=Ye J |title=Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. |journal=PLoS Pathog. |volume=3 |issue= 8 |pages= e108 |year= 2007 |pmid= 17784784 |doi= 10.1371/journal.ppat.0030108
*cite journal | author=Bradbury LE, Kansas GS, Levy S, "et al." |title=The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. |journal=J. Immunol. |volume=149 |issue= 9 |pages= 2841–50 |year= 1992 |pmid= 1383329 |doi=
*cite journal | author=Andria ML, Hsieh CL, Oren R, "et al." |title=Genomic organization and chromosomal localization of the TAPA-1 gene. |journal=J. Immunol. |volume=147 |issue= 3 |pages= 1030–6 |year= 1991 |pmid= 1650385 |doi=
*cite journal | author=Oren R, Takahashi S, Doss C, "et al." |title=TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. |journal=Mol. Cell. Biol. |volume=10 |issue= 8 |pages= 4007–15 |year= 1990 |pmid= 1695320 |doi=
*cite journal | author=Levy S, Nguyen VQ, Andria ML, Takahashi S |title=Structure and membrane topology of TAPA-1. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14597–602 |year= 1991 |pmid= 1860863 |doi=
*cite journal | author=Takahashi S, Doss C, Levy S, Levy R |title=TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. |journal=J. Immunol. |volume=145 |issue= 7 |pages= 2207–13 |year= 1990 |pmid= 2398277 |doi=
*cite journal | author=Matsumoto AK, Martin DR, Carter RH, "et al." |title=Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes. |journal=J. Exp. Med. |volume=178 |issue= 4 |pages= 1407–17 |year= 1993 |pmid= 7690834 |doi=
*cite journal | author=Nagira M, Imai T, Ishikawa I, "et al." |title=Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression. |journal=Cell. Immunol. |volume=157 |issue= 1 |pages= 144–57 |year= 1994 |pmid= 8039242 |doi= 10.1006/cimm.1994.1212
*cite journal | author=Virtaneva KI, Emi N, Marken JS, "et al." |title=Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins. |journal=Immunogenetics |volume=39 |issue= 5 |pages= 329–34 |year= 1994 |pmid= 8168850 |doi=
*cite journal | author=Radford KJ, Thorne RF, Hersey P |title=CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 1 |pages= 13–8 |year= 1996 |pmid= 8630057 |doi= 10.1006/bbrc.1996.0690
*cite journal | author=Szöllósi J, Horejsí V, Bene L, "et al." |title=Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. |journal=J. Immunol. |volume=157 |issue= 7 |pages= 2939–46 |year= 1996 |pmid= 8816400 |doi=
*cite journal | author=Berditchevski F, Tolias KF, Wong K, "et al." |title=A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2595–8 |year= 1997 |pmid= 9006891 |doi=
*cite journal | author=Berditchevski F, Chang S, Bodorova J, Hemler ME |title=Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29174–80 |year= 1997 |pmid= 9360995 |doi=
*cite journal | author=Tachibana I, Bodorova J, Berditchevski F, "et al." |title=NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29181–9 |year= 1997 |pmid= 9360996 |doi=
*cite journal | author=Hu RJ, Lee MP, Connors TD, "et al." |title=A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. |journal=Genomics |volume=46 |issue= 1 |pages= 9–17 |year= 1998 |pmid= 9403053 |doi= 10.1006/geno.1997.4981
*cite journal | author=Pileri P, Uematsu Y, Campagnoli S, "et al." |title=Binding of hepatitis C virus to CD81. |journal=Science |volume=282 |issue= 5390 |pages= 938–41 |year= 1998 |pmid= 9794763 |doi=
*cite journal | author=Serru V, Le Naour F, Billard M, "et al." |title=Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. |journal=Biochem. J. |volume=340 ( Pt 1) |issue= |pages= 103–11 |year= 1999 |pmid= 10229664 |doi=
*cite journal | author=Tachibana I, Hemler ME |title=Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. |journal=J. Cell Biol. |volume=146 |issue= 4 |pages= 893–904 |year= 1999 |pmid= 10459022 |doi=
*cite journal | author=Higginbottom A, Quinn ER, Kuo CC, "et al." |title=Identification of amino acid residues in CD81 critical for interaction with hepatitis C virus envelope glycoprotein E2. |journal=J. Virol. |volume=74 |issue= 8 |pages= 3642–9 |year= 2000 |pmid= 10729140 |doi=

External links


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