enzymology, a dTMP kinase (EC number|18.104.22.168) is an enzymethat catalyzes the chemical reaction
:ATP + dTMP ADP + dTDP
This enzyme belongs to the family of
transferases, specifically those transferring phosphorus-containing groups ( phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:dTMP phosphotransferase. Other names in common use include thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, and thymidine 5'-monophosphate kinase. This enzyme participates in pyrimidine metabolism.
As of late 2007, 40 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1E2D, PDB link|1E2E, PDB link|1E2F, PDB link|1E2G, PDB link|1E2Q, PDB link|1E98, PDB link|1E99, PDB link|1E9A, PDB link|1E9B, PDB link|1E9C, PDB link|1E9D, PDB link|1E9E, PDB link|1E9F, PDB link|1G3U, PDB link|1GSI, PDB link|1GTV, PDB link|1MRN, PDB link|1MRS, PDB link|1N5I, PDB link|1N5J, PDB link|1N5K, PDB link|1N5L, PDB link|1NMX, PDB link|1NMY, PDB link|1NMZ, PDB link|1NN0, PDB link|1NN1, PDB link|1NN3, PDB link|1NN5, PDB link|1TMK, PDB link|1W2G, PDB link|1W2H, PDB link|2CCG, PDB link|2CCJ, PDB link|2CCK, PDB link|2PBR, PDB link|2TMK, PDB link|3TMK, PDB link|4TMK, and PDB link|5TMP.
CAS registry numberfor this enzyme class is CAS registry|9014-43-1."
Gene Ontology (GO) codes
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